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Generated: December 18, 2017

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Details for Patent: 5,270,057

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Summary for Patent: 5,270,057

Title: Stabilized gonadotropin containing preparations
Abstract:Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular stabilizer in lyophilized form. The preparations contain a sufficient amount of dicarboxylic acid salt to stabilize the protein in freeze-dried form for a desired time at a desired temperature. Typical dicarboxylic acid salts disclosed are the salts of citric, tartaric, and aspartic acids. The preparations preferably include a non-reducing disaccharide to increase the collapse temperature of the solution to be lyophilized. Methods of making the preparations in lyophilized form and the resulting injectable preparations are also disclosed.
Inventor(s): de Meere; Andreas L. J. (Waspik, NL), De Ruiter; Marinus A. (Oss, NL)
Assignee: Akzo N.V. (Arnhem, NL)
Application Number:07/914,227
Patent Claim Types:
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Composition; Formulation;

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Foreign Priority and PCT Information for Patent: 5,270,057

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
90.200665.9Mar 20, 1990

International Patent Family for Patent: 5,270,057

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Canada2037884► Subscribe
Germany69102465► Subscribe
Denmark0448146► Subscribe
European Patent Office0448146► Subscribe
Spain2057731► Subscribe
Finland911309► Subscribe
Finland101194► Subscribe
Australia631730► Subscribe
Australia7362391► Subscribe
Austria107172► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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Serving leading biopharmaceutical companies globally:

US Army
Express Scripts
Johnson and Johnson
Daiichi Sankyo

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