Details for Patent: 5,137,711

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Summary for Patent: 5,137,711

Title:	Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
Abstract:	Novel magnetic resonance imaging agents methods utilize complexes of paramagnetic ions with alkoxyalkylamide deriviatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetyraacetic acid ("EDTA"). These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.The complexes are represented by the following formula: ##STR1## wherein A is --CH2 CH2 -- or ##STR2## and M+Z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 or 58-70, and a valence number, Z, of 2 or 3; R1 is --O- or R3 --N--R2, R2 is --(CH2 CH2 O)n --R4, n is 1-10, R4 is alkyl or aryl, R3 is H, R2, alkyl, hydroxy, alkoxy, cycloalkyl or aryl, wherein Z of the R1 groups are --O- and the remainder of the R1 groups are R2 -N--R3 groups.
Inventor(s):	Robert W. Weber, Muthunadar P. Periasamy
Assignee:	Mallinckrodt Inc
Application Number:	US07/377,491
Patent Claim Types: see list of patent claims	Use; Composition; Dosage form;

Drugs Protected by US Patent 5,137,711

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 5,137,711

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	0425571		07C0052	France
European Patent Office	0425571		300299	Netherlands
European Patent Office	0425571		SPC/GB07/052	United Kingdom