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Serving leading biopharmaceutical companies globally:

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Generated: January 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,137,711

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Summary for Patent: 5,137,711
Title: Paramagnetic DTPA and EDTA alkoxyalkylamide complexes as MRI agents
Abstract:Novel magnetic resonance imaging agents methods utilize complexes of paramagnetic ions with alkoxyalkylamide deriviatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetyraacetic acid ("EDTA"). These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. The complexes are represented by the following formula: ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or ##STR2## and M.sup.+Z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 or 58-70, and a valence number, Z, of 2 or 3; R.sup.1 is --O.sup.- or R.sup.3 --N--R.sup.2, R.sup.2 is --(CH.sub.2 CH.sub.2 O).sub.n --R.sup.4, n is 1-10, R.sup.4 is alkyl or aryl, R.sup.3 is H, R.sup.2, alkyl, hydroxy, alkoxy, cycloalkyl or aryl, wherein Z of the R.sup.1 groups are --O.sup.- and the remainder of the R.sup.1 groups are R.sup.2 -N--R.sup.3 groups.
Inventor(s): Weber; Robert W. (Downingtown, PA), Periasamy; Muthunadar P. (Creve Coeur, MO)
Assignee: Mallickrodt Medical, Inc. (St. Louis, MO)
Application Number:07/377,491
Patent Claim Types:
see list of patent claims
Compound; Composition; Dosage form; Use;

Drugs Protected by US Patent 5,137,711

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,137,711

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 142614 ➤ Subscribe
Australia 3988589 ➤ Subscribe
Australia 650615 ➤ Subscribe
Brazil 1101072 ➤ Subscribe
Canada 1339821 ➤ Subscribe
Germany 122007000068 ➤ Subscribe
Germany 68927173 ➤ Subscribe
European Patent Office 0425571 ➤ Subscribe 07C0052 France ➤ Subscribe
European Patent Office 0425571 ➤ Subscribe 300299 Netherlands ➤ Subscribe
European Patent Office 0425571 ➤ Subscribe SPC/GB07/052 United Kingdom ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Novartis
Accenture
Citi
Cantor Fitzgerald
US Army
Express Scripts
Covington
QuintilesIMS

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