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Last Updated: December 12, 2025

Claims for Patent: 5,137,711

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Summary for Patent: 5,137,711

Title:	Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
Abstract:	Novel magnetic resonance imaging agents methods utilize complexes of paramagnetic ions with alkoxyalkylamide deriviatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetyraacetic acid ("EDTA"). These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. The complexes are represented by the following formula: ##STR1## wherein A is --CH2 CH2 -- or ##STR2## and M+Z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 or 58-70, and a valence number, Z, of 2 or 3; R1 is --O- or R3 --N--R2, R2 is --(CH2 CH2 O)n --R4, n is 1-10, R4 is alkyl or aryl, R3 is H, R2, alkyl, hydroxy, alkoxy, cycloalkyl or aryl, wherein Z of the R1 groups are --O- and the remainder of the R1 groups are R2 -N--R3 groups.
Inventor(s):	Robert W. Weber, Muthunadar P. Periasamy
Assignee:	Mallinckrodt Inc
Application Number:	US07/377,491
Patent Claims:

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