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Generated: December 14, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,992,554

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Summary for Patent: 4,992,554

Title: Dipyridoxyl phosphate chelating compounds
Abstract:N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective NMRI contrast agents. Preferred contrast agents are paramagnetic ion chelates of N,N'-bis-(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-cyclohexylenediamine-N,N'-diacet ic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N'-diacetic acid, and the soluble calcium salts thereof. Novel intermediates for forming these compounds are N,N'-bis(pyridoxal-5-phosphate)alkylenediimines, N,N'-bis(pyridoxal-5-phosphate)alkylenediamines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediimines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediamines, N,N'-bis(pyridoxal-5-phosphate-1,2-arylenediamines, and the corresponding monophosphate compounds.
Inventor(s): Rocklage; Scott M. (Saratoga, CA), Quay; Steven C. (Los Altos Hills, CA)
Assignee: Salutar, Inc. (Sunnyvale, CA)
Application Number:07/370,430
Patent Claim Types:
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Compound;

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International Patent Family for Patent: 4,992,554

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Germany19775088► Subscribe
Finland88164► Subscribe
Germany3852906► Subscribe
Denmark251688► Subscribe
Denmark173849► Subscribe
European Patent Office0290047► SubscribeC00290047/01Switzerland► Subscribe
European Patent Office0290047► SubscribeSPC/GB97/078United Kingdom► Subscribe
European Patent Office0290047► Subscribe97C0108Belgium► Subscribe
European Patent Office0290047► Subscribe67/1997Austria► Subscribe
Spain2066768► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Harvard Business School
McKesson
QuintilesIMS
Dow
Fish and Richardson
Accenture
Baxter
Cerilliant
Medtronic

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