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Generated: December 16, 2017

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Details for Patent: 4,992,474

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Summary for Patent: 4,992,474

Title: Phenethanolamine derivatives
Abstract:Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R.sup.1 and R.sup.2 are hydrogen or alkyl provided that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 4; and the physiologically acceptable salts and solvates thereof. The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients. The compounds may be prepared, for example by alkylation of an amine: ##STR2## where R.sup.3, R.sup.5 and R.sup.6 is hydrogen or a protecting group, followed by removal of any protecting group.
Inventor(s): Skidmore; Ian F. (Welwyn, GB2), Lunts; Lawrence H. C. (Broxbourne, GB2), Finch; Harry (Hitchin, GB2), Naylor; Alan (Royston, GB2)
Assignee: Glaxo Group Ltd. (London, GB2)
Application Number:07/397,664
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

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Foreign Priority and PCT Information for Patent: 4,992,474

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8310477Apr 18, 1983
United Kingdom8317087Jun 23, 1983
United Kingdom8329568Nov 04, 1983
United Kingdom8401889Jan 25, 1984

International Patent Family for Patent: 4,992,474

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
United Kingdom2176476► Subscribe
EcuadorSP941094► Subscribe
Spain531722► Subscribe
Denmark158092► Subscribe
Denmark175083► Subscribe
Denmark201784► Subscribe
United Kingdom8612357► Subscribe
United Kingdom2140800► Subscribe
United Kingdom8410124► Subscribe
France2545482► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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