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Generated: December 10, 2017

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Claims for Patent: 4,992,474

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Claims for Patent: 4,992,474

Title: Phenethanolamine derivatives
Abstract:Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R.sup.1 and R.sup.2 are hydrogen or alkyl provided that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 4; and the physiologically acceptable salts and solvates thereof. The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients. The compounds may be prepared, for example by alkylation of an amine: ##STR2## where R.sup.3, R.sup.5 and R.sup.6 is hydrogen or a protecting group, followed by removal of any protecting group.
Inventor(s): Skidmore; Ian F. (Welwyn, GB2), Lunts; Lawrence H. C. (Broxbourne, GB2), Finch; Harry (Hitchin, GB2), Naylor; Alan (Royston, GB2)
Assignee: Glaxo Group Ltd. (London, GB2)
Application Number:07/397,664
Patent Claims: 1. 4-Hydr oxy-alpha'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol,1 -hydroxy-2-naphthalenecarboxylate.

2. 4-Hydroxy-alpha'-[[[6-(4-phenyl butoxy)hexyl]amino]methyl]-1,3-benzenedimethanol and its physiologically acceptable salts and solvates.

3. A pharmaceutical composition comprising the compound of claim 1 together with one or more physiologically acceptable carriers or excipients.

4. A pharmaceutical composition comprising at least one of the compounds of claim 2, together with one or more physiologically acceptable carriers or excipients.

5. 4-Hydroxy -alpha'-[[[6-(3-phenylpropoxy)hexyl]amino]methyl]1,3-benzenedimethanol and its physiologically acceptable salts and solvates.

6. A pharmaceutical composition comprising at least one of the compounds of claim 5, together with one or more physiologically acceptable carriers or excipients.

7. A method of treating a patient suffering from a disease associated with reversible airways obstruction which comprises administering to the patient an effective amount of the compound of claim 1.

8. A method of treating a patient suffering from a disease associated with reversible airways obstruction which comprises administering to the patient an effective amount of at least one of the compounds of claim 2.

9. A method of treating a patient suffering from a disease associated with reversible airways obstruction which comprises administering to the patient an effective amount of at least one of the compounds of claim 5.

10. A method according to claim 7, wherein the disease is asthma or chronic bronchitis.

11. A method according to claim 8, wherein the disease is asthma or chronic bronchitis.

12. A method according to claim 9, wherein the disease is asthma or chronic bronchitis.
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Serving leading biopharmaceutical companies globally:

US Army
Federal Trade Commission
AstraZeneca
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Express Scripts
Citi
Medtronic
Deloitte
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Johnson and Johnson

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