.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,992,474

« Back to Dashboard

Claims for Patent: 4,992,474

Title: Phenethanolamine derivatives
Abstract:Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R.sup.1 and R.sup.2 are hydrogen or alkyl provided that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 4; and the physiologically acceptable salts and solvates thereof. The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients. The compounds may be prepared, for example by alkylation of an amine: ##STR2## where R.sup.3, R.sup.5 and R.sup.6 is hydrogen or a protecting group, followed by removal of any protecting group.
Inventor(s): Skidmore; Ian F. (Welwyn, GB2), Lunts; Lawrence H. C. (Broxbourne, GB2), Finch; Harry (Hitchin, GB2), Naylor; Alan (Royston, GB2)
Assignee: Glaxo Group Ltd. (London, GB2)
Application Number:07/397,664
Patent Claims: 1. 4-Hydr oxy-alpha'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol,1 -hydroxy-2-naphthalenecarboxylate.

2. 4-Hydroxy-alpha'-[[[6-(4-phenyl butoxy)hexyl]amino]methyl]-1,3-benzenedimethanol and its physiologically acceptable salts and solvates.

3. A pharmaceutical composition comprising the compound of claim 1 together with one or more physiologically acceptable carriers or excipients.

4. A pharmaceutical composition comprising at least one of the compounds of claim 2, together with one or more physiologically acceptable carriers or excipients.

5. 4-Hydroxy -alpha'-[[[6-(3-phenylpropoxy)hexyl]amino]methyl]1,3-benzenedimethanol and its physiologically acceptable salts and solvates.

6. A pharmaceutical composition comprising at least one of the compounds of claim 5, together with one or more physiologically acceptable carriers or excipients.

7. A method of treating a patient suffering from a disease associated with reversible airways obstruction which comprises administering to the patient an effective amount of the compound of claim 1.

8. A method of treating a patient suffering from a disease associated with reversible airways obstruction which comprises administering to the patient an effective amount of at least one of the compounds of claim 2.

9. A method of treating a patient suffering from a disease associated with reversible airways obstruction which comprises administering to the patient an effective amount of at least one of the compounds of claim 5.

10. A method according to claim 7, wherein the disease is asthma or chronic bronchitis.

11. A method according to claim 8, wherein the disease is asthma or chronic bronchitis.

12. A method according to claim 9, wherein the disease is asthma or chronic bronchitis.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc