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Generated: August 22, 2017
| Title: | Novel chlorthalidone process and product |
| Abstract: | Water-soluble dispersions of chlorthalidone are prepared by a process comprising: (a) forming a solution comprising a water soluble pharmaceutically acceptable polymeric carrier and a C.sub.1 -C.sub.4 alkanol, (b) dissolving chlorthalidone in the solution thus formed, and (c) removing the C.sub.1 -C.sub.4 alkanol from the solution by evaporation, the amount of said carrier being effective to suppress substantially the formation of the alkyl ether by-product from the reaction of chlorthalidone with the C.sub.1 -C.sub.4 alkanol. A preferred water soluble carrier is polyvinylpyrrolidone and a preferred C.sub.1 -C.sub.4 alkanol is methanol. |
| Inventor(s): | Pandit; Nivedita (Middlebury, CT), Horhota; Stephen T. (Brookfield, CT) |
| Assignee: | Boehringer Ingelheim Pharmaceuticals, Inc. (Ridgefield, CT) |
| Application Number: | 06/796,467 |
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Patent Claim Types: see list of patent claims | Process; Formulation; Composition; Dosage form; Use; |
| Country | Document Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Australia | 2569684 | ► Subscribe | |||||||||||||||||||||||||||
| Australia | 562929 | ► Subscribe | |||||||||||||||||||||||||||
| Canada | 1212329 | ► Subscribe | |||||||||||||||||||||||||||
| German Democratic Republic | 220225 | ► Subscribe | |||||||||||||||||||||||||||
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