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|Title:||Novel chlorthalidone process and product|
|Abstract:||Water-soluble dispersions of chlorthalidone are prepared by a process comprising: (a) forming a solution comprising a water soluble pharmaceutically acceptable polymeric carrier and a C.sub.1 -C.sub.4 alkanol, (b) dissolving chlorthalidone in the solution thus formed, and (c) removing the C.sub.1 -C.sub.4 alkanol from the solution by evaporation, the amount of said carrier being effective to suppress substantially the formation of the alkyl ether by-product from the reaction of chlorthalidone with the C.sub.1 -C.sub.4 alkanol. A preferred water soluble carrier is polyvinylpyrrolidone and a preferred C.sub.1 -C.sub.4 alkanol is methanol.|
|Inventor(s):||Pandit; Nivedita (Middlebury, CT), Horhota; Stephen T. (Brookfield, CT)|
|Assignee:||Boehringer Ingelheim Pharmaceuticals, Inc. (Ridgefield, CT)|
Patent Claim Types:|
see list of patent claims
|Process; Formulation; Composition; Dosage form; Use;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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