Details for Patent: 4,789,736
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Summary for Patent: 4,789,736
Title: | Complexes of technetium-99m with propylene amine oximes |
Abstract: | A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R.sup.1 is Cl-C4 alkyl or phenyl and each of R, R.sup.2, R.sup.3 and R.sup.4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R.sup.1 =R.sup.2 =CH.sub.3, R.sup.3 =R.sup.4 =H) show good retention in the brain. |
Inventor(s): | Canning; Lewis R. (Herts, GB2), Nowotnik; David P. (Bucks, GB2), Neirinckx; Rudi D. (Bucks, GB2), Piper; Ian M. (Herts, GB2) |
Assignee: | Amersham International plc (Bucks, GB2) |
Application Number: | 06/838,558 |
Patent Claim Types: see list of patent claims | Compound; |
Drugs Protected by US Patent 4,789,736
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Foreign Priority and PCT Information for Patent: 4,789,736
International Family Members for US Patent 4,789,736
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