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Generated: January 18, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,789,736

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Summary for Patent: 4,789,736
Title: Complexes of technetium-99m with propylene amine oximes
Abstract:A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R.sup.1 is Cl-C4 alkyl or phenyl and each of R, R.sup.2, R.sup.3 and R.sup.4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R.sup.1 =R.sup.2 =CH.sub.3, R.sup.3 =R.sup.4 =H) show good retention in the brain.
Inventor(s): Canning; Lewis R. (Herts, GB2), Nowotnik; David P. (Bucks, GB2), Neirinckx; Rudi D. (Bucks, GB2), Piper; Ian M. (Herts, GB2)
Assignee: Amersham International plc (Bucks, GB2)
Application Number:06/838,558
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 4,789,736

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,789,736

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8506249Mar 11, 1985
United Kingdom8509368Apr 12, 1985

International Patents Family Members for US Patent 4,789,736

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 5460986 ➤ Subscribe
Australia 577931 ➤ Subscribe
Canada 1243329 ➤ Subscribe
Canada 1252481 ➤ Subscribe
Germany 3687467 ➤ Subscribe
European Patent Office 0194843 ➤ Subscribe
United Kingdom 8506249 ➤ Subscribe
United Kingdom 8509368 ➤ Subscribe
Hong Kong 97997 ➤ Subscribe
Japan 2547515 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

US Department of Justice
Julphar
Cipla
Farmers Insurance
McKinsey
Fuji
Covington
US Army
Express Scripts

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