Details for Patent: 4,789,736

Summary for Patent: 4,789,736

Title:	Complexes of technetium-99m with propylene amine oximes
Abstract:	A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R1 is Cl-C4 alkyl or phenyl and each of R, R2, R3 and R4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R1 =R2 =CH3, R3 =R4 =H) show good retention in the brain.
Inventor(s):	Lewis R. Canning, David P. Nowotnik, Rudi D. Neirinckx, Ian M. Piper
Assignee:	GE Healthcare Ltd
Application Number:	US06/838,558
Patent Claim Types: see list of patent claims	Compound;

Drugs Protected by US Patent 4,789,736

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 4,789,736

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
United Kingdom	8506249	Mar 11, 1985
United Kingdom	8509368	Apr 12, 1985

International Family Members for US Patent 4,789,736

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	5460986
Australia	577931
Canada	1243329
Canada	1252481
Germany	3687467
European Patent Office	0194843