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Generated: May 23, 2018

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Details for Patent: 4,789,736

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Summary for Patent: 4,789,736
Title: Complexes of technetium-99m with propylene amine oximes
Abstract:A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R.sup.1 is Cl-C4 alkyl or phenyl and each of R, R.sup.2, R.sup.3 and R.sup.4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R.sup.1 =R.sup.2 =CH.sub.3, R.sup.3 =R.sup.4 =H) show good retention in the brain.
Inventor(s): Canning; Lewis R. (Herts, GB2), Nowotnik; David P. (Bucks, GB2), Neirinckx; Rudi D. (Bucks, GB2), Piper; Ian M. (Herts, GB2)
Assignee: Amersham International plc (Bucks, GB2)
Application Number:06/838,558
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 4,789,736

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,789,736

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8506249Mar 11, 1985
United Kingdom8509368Apr 12, 1985

International Family Members for US Patent 4,789,736

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Canada 1243329 ➤ Try a Free Trial
Canada 1252481 ➤ Try a Free Trial
Germany 3687467 ➤ Try a Free Trial
European Patent Office 0194843 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

McKinsey
Chinese Patent Office
Citi
Colorcon
Federal Trade Commission
Farmers Insurance
Baxter
Julphar
UBS

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