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Last Updated: December 12, 2025

Claims for Patent: 4,789,736

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Summary for Patent: 4,789,736

Title:	Complexes of technetium-99m with propylene amine oximes
Abstract:	A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R1 is Cl-C4 alkyl or phenyl and each of R, R2, R3 and R4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R1 =R2 =CH3, R3 =R4 =H) show good retention in the brain.
Inventor(s):	Lewis R. Canning, David P. Nowotnik, Rudi D. Neirinckx, Ian M. Piper
Assignee:	GE Healthcare Ltd
Application Number:	US06/838,558
Patent Claims:

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