Details for Patent: 4,757,128

Summary for Patent: 4,757,128

Title:	High molecular weight polyanhydride and preparation thereof
Abstract:	High molecular weight polyanhydrides, defined as polyanhydrides having a molecular weight average greater than 20,000 or an intrinsic viscosity of greater than 0.3 dl/g in an organic solvent at room temperature, are formed by melt polycondensation of highly pure isolated prepolymers under optimized reaction conditions, particularly time and temperature with removal of the condensation product. Higher molecular weights are obtained by inclusion of a catalyst with the prepolymers in the melt polymerization. Catalysts used for transterification, ring opening polymerization and related polymerizations may be utilized. The high molecular weight polyanhydrides have improved physico-mechanical properties and are especially well suited for biomedical applications, particularly in controlled release devices for drug delivery.
Inventor(s):	Domb; Abraham J. (Brookline, MA), Langer; Robert S. (Somerville, MA)
Assignee:	Massachusetts Institute of Technology (Cambridge, MA)
Application Number:	06/892,809
Patent Claim Types: see list of patent claims	Compound; Composition; Use;

Drugs Protected by US Patent 4,757,128

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 4,757,128

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	141804
Austria	145657
Canada	1274339
Canada	2056384
Germany	260415
Germany	3751964
Germany	69028303