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Last Updated: December 12, 2025

Claims for Patent: 4,757,128

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Summary for Patent: 4,757,128

Title:	High molecular weight polyanhydride and preparation thereof
Abstract:	High molecular weight polyanhydrides, defined as polyanhydrides having a molecular weight average greater than 20,000 or an intrinsic viscosity of greater than 0.3 dl/g in an organic solvent at room temperature, are formed by melt polycondensation of highly pure isolated prepolymers under optimized reaction conditions, particularly time and temperature with removal of the condensation product. Higher molecular weights are obtained by inclusion of a catalyst with the prepolymers in the melt polymerization. Catalysts used for transterification, ring opening polymerization and related polymerizations may be utilized. The high molecular weight polyanhydrides have improved physico-mechanical properties and are especially well suited for biomedical applications, particularly in controlled release devices for drug delivery.
Inventor(s):	Abraham J. Domb, Robert S. Langer
Assignee:	Massachusetts Institute of Technology, Artery LLC
Application Number:	US06/892,809
Patent Claims:

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