|Title:||Pharmaceutical preparations containing cyclodextrin derivatives|
|Abstract:||The invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This improves the dissolution properties of the drug and hence its absorption by the body. The required cyclodextrin-based mixtures were prepared from .alpha.-, .beta.-, or .gamma.-cyclodextrin which were rendered amorphous through non-selective alkylation. The alkylation agents suitable for that purposes are exemplified by propylene oxide, glycidol, iodoacetamide, chloroacetate, or 2-diethylaminoethylchloride; their reactions with cyclodextrins were performed in a manner to yield mixtures containing many components, a circumstance which effectively prevents crystallization processes within the above pharmaceutical preparation.|
|Inventor(s):||Pitha; Josef (Baltimore, MD)|
|Assignee:||The United States of America as represented by the Department of Health (Washington, DC)|
Patent Claim Types:|
see list of patent claims
|Use; Formulation; Composition; Dosage form; Process;|
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