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Details for Patent: 4,727,064

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Summary for Patent: 4,727,064

Title: Pharmaceutical preparations containing cyclodextrin derivatives
Abstract:The invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This improves the dissolution properties of the drug and hence its absorption by the body. The required cyclodextrin-based mixtures were prepared from .alpha.-, .beta.-, or .gamma.-cyclodextrin which were rendered amorphous through non-selective alkylation. The alkylation agents suitable for that purposes are exemplified by propylene oxide, glycidol, iodoacetamide, chloroacetate, or 2-diethylaminoethylchloride; their reactions with cyclodextrins were performed in a manner to yield mixtures containing many components, a circumstance which effectively prevents crystallization processes within the above pharmaceutical preparation.
Inventor(s): Pitha; Josef (Baltimore, MD)
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Application Number:06/738,749
Patent Claim Types:
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Use; Formulation; Composition; Dosage form; Process;

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