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Generated: December 15, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,721,619

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Summary for Patent: 4,721,619

Title: Controlled absorption diltiazen pharmaceutical formulation
Abstract:A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane which permits release of diltiazem in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured according to the Paddle Method of U.S. Pharmacopoeia XX, is not more than 10% of the total diltiazem after 2 hours of measurement in a buffered medium. Not more than 30% of the total diltiazem is released after a total of 4 hours measurement and not more than 40% of the total diltiazem is released after a total of 6 hours. 100% release is achieved after 12 hours, with a maximum of 80% of the total diltiazem being released after 8 hours.
Inventor(s): Panoz; Donald E. (Whale Bay, BM), Geoghegan; Edward J. (Athlone, IE)
Assignee: Elan Corporation p.l.c. (IE)
Application Number:06/684,661
Patent Claim Types:
see list of patent claims
Composition; Formulation; Compound; Dosage form;

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Foreign Priority and PCT Information for Patent: 4,721,619

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Ireland3057/83Dec 22, 1983

International Patent Family for Patent: 4,721,619

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office0149920► Subscribe
European Patent Office0320097► Subscribe
European Patent Office0856313► Subscribe
Spain2194832► Subscribe
Ireland833057► Subscribe
Ireland56999► Subscribe
Ireland60929► Subscribe
Ireland872790► Subscribe
Switzerland662507► Subscribe
Germany3485023► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

US Army
Farmers Insurance
Queensland Health
Johnson and Johnson

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