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Last Updated: December 12, 2025

Claims for Patent: 4,721,619

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Summary for Patent: 4,721,619

Title:	Controlled absorption diltiazen pharmaceutical formulation
Abstract:	A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane which permits release of diltiazem in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured according to the Paddle Method of U.S. Pharmacopoeia XX, is not more than 10% of the total diltiazem after 2 hours of measurement in a buffered medium. Not more than 30% of the total diltiazem is released after a total of 4 hours measurement and not more than 40% of the total diltiazem is released after a total of 6 hours. 100% release is achieved after 12 hours, with a maximum of 80% of the total diltiazem being released after 8 hours.
Inventor(s):	Donald E. Panoz, Edward J. Geoghegan
Assignee:	Perrigo Co PLC
Application Number:	US06/684,661
Patent Claims:

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