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Serving leading biopharmaceutical companies globally:

Chinese Patent Office
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US Army
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Generated: January 23, 2018

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Details for Patent: 4,703,035

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Summary for Patent: 4,703,035
Title: Human pancreatic GRF amidated fragments
Abstract:Surprisingly active fragments of human pancreatic GRF have been synthesized which exhibit good biological activity. These synthetic peptides are extremely potent in stimulating the release of pituitary GH in humans and in nonhuman animals and have the general formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Y wherein Y is NH.sub.2, Gln-NH.sub.2, Gln-Gln-NH.sub.2 or Gln-Gln-Gly-NH.sub.2. Two such fragments have been tested, namely the 29 and the 32 N-terminal residue sequences that are amidated at the C-terminus. These peptides, as well as nontoxic salts thereof, may be administered therapeutically to animals, including humans.
Inventor(s): Rivier; Jean E. F. (La Jolla, CA), Spiess; Joachim (Encinitas, CA), Vale, Jr.; Wylie W. (La Jolla, CA)
Assignee: The Salk Institute for Biological Studies (San Diego, CA)
Application Number:06/782,912
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 4,703,035

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 4,703,035

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 241452 ➤ Subscribe
Austria 24919 ➤ Subscribe
Austria 25851 ➤ Subscribe
Austria 36862 ➤ Subscribe
Austria 73823 ➤ Subscribe
Australia 2126983 ➤ Subscribe
Australia 2307584 ➤ Subscribe
Australia 3259484 ➤ Subscribe
Australia 4248885 ➤ Subscribe
Australia 557046 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Argus Health
Cantor Fitzgerald
AstraZeneca
Cipla
Teva
Chubb
Harvard Business School
QuintilesIMS
Mallinckrodt

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