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Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
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Queensland Health
Chubb
Citi
Healthtrust
Cipla
Merck
Covington

Generated: April 24, 2018

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Details for Patent: 4,703,035

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Summary for Patent: 4,703,035
Title: Human pancreatic GRF amidated fragments
Abstract:Surprisingly active fragments of human pancreatic GRF have been synthesized which exhibit good biological activity. These synthetic peptides are extremely potent in stimulating the release of pituitary GH in humans and in nonhuman animals and have the general formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Y wherein Y is NH.sub.2, Gln-NH.sub.2, Gln-Gln-NH.sub.2 or Gln-Gln-Gly-NH.sub.2. Two such fragments have been tested, namely the 29 and the 32 N-terminal residue sequences that are amidated at the C-terminus. These peptides, as well as nontoxic salts thereof, may be administered therapeutically to animals, including humans.
Inventor(s): Rivier; Jean E. F. (La Jolla, CA), Spiess; Joachim (Encinitas, CA), Vale, Jr.; Wylie W. (La Jolla, CA)
Assignee: The Salk Institute for Biological Studies (San Diego, CA)
Application Number:06/782,912
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 4,703,035

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Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Czechoslovakia 8406901 ➤ Sign Up
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Czechoslovakia 8400200 ➤ Sign Up
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Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Daiichi Sankyo
Argus Health
Baxter
QuintilesIMS
US Department of Justice
Healthtrust
Johnson and Johnson
Boehringer Ingelheim

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