|Title:||Human pancreatic GRF amidated fragments|
|Abstract:||Surprisingly active fragments of human pancreatic GRF have been synthesized which exhibit good biological activity. These synthetic peptides are extremely potent in stimulating the release of pituitary GH in humans and in nonhuman animals and have the general formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Y wherein Y is NH.sub.2, Gln-NH.sub.2, Gln-Gln-NH.sub.2 or Gln-Gln-Gly-NH.sub.2. Two such fragments have been tested, namely the 29 and the 32 N-terminal residue sequences that are amidated at the C-terminus. These peptides, as well as nontoxic salts thereof, may be administered therapeutically to animals, including humans.|
|Inventor(s):||Rivier; Jean E. F. (La Jolla, CA), Spiess; Joachim (Encinitas, CA), Vale, Jr.; Wylie W. (La Jolla, CA)|
|Assignee:||The Salk Institute for Biological Studies (San Diego, CA)|
Patent Claim Types:|
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|Compound; Composition; Use;|
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