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Last Updated: December 12, 2025

Claims for Patent: 4,703,035

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Summary for Patent: 4,703,035

Title:	Human pancreatic GRF amidated fragments
Abstract:	Surprisingly active fragments of human pancreatic GRF have been synthesized which exhibit good biological activity. These synthetic peptides are extremely potent in stimulating the release of pituitary GH in humans and in nonhuman animals and have the general formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Y wherein Y is NH2, Gln-NH2, Gln-Gln-NH2 or Gln-Gln-Gly-NH2. Two such fragments have been tested, namely the 29 and the 32 N-terminal residue sequences that are amidated at the C-terminus. These peptides, as well as nontoxic salts thereof, may be administered therapeutically to animals, including humans.
Inventor(s):	Jean E. F. Rivier, Joachim Spiess, Wylie W. Vale, Jr.
Assignee:	Salk Institute for Biological Studies
Application Number:	US06/782,912
Patent Claims:

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