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|Abstract:||A steroid derivative of the formula: wherein ST is a 7.alpha.-linked steroid nucleus of the general formula: ##STR1## wherein the double bond(s) between carbon atoms 6 and 7 and/or carbon atoms 8 and 9 are optional; wherein the aromatic ring A may optionally bear one or two halogen or alkyl substituents; wherein R.sup.3 is hydrogen, alkyl, or acyl; wherein R.sup.16 is hydrogen, alkyl or hydroxy; wherein either R.sup.17 is hydroxy or acyloxy and R.sup.27 is hydrogen, alkyl, alkenyl or alkynyl, or R.sup.17 and R.sup.27 together form oxo (.dbd.O); wherein R.sup.18 is alkyl; wherein A is alkylene, alkenylene or alkynylene optionally fluorinated and optionally interrupted by --O--, --S--, --SO--, --SO.sub.2 --, --CO--, --NR--, --NRCO--, --CONR--, --COO--, --OCO-- or phenylene, wherein R is hydrogen or alkyl; wherein R.sup.1 is hydrogen, alkyl, alkenyl, cycloalkyl, halogenoalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl, arylalkyl, or dialkylaminoalkyl, or R.sup.1 is joined to R.sup.2 as defined below; and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR2## --SO.sub.2 NR.sup.2 -- or --CO--; or, when R.sup.1 is not hydrogen, is --O--, --NR.sup.2 --, --(NO)R.sup.2 --, --(PO)R.sup.2 --, --NR.sup.12 COO--; --NR.sup.12 SO.sub.2 --, --S--, --SO-- or --SO.sub.2 --; wherein R.sup.2 is hydrogen or alkyl or R.sup.1 and R.sup.2 together form alkylene or halogenoalkylene; wherein R.sup.12 is hydrogen or alkyl and wherein R.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.|
|Inventor(s):||Bowler; Jean (Sandbach, GB), Tait; Brian S. (Macclesfield, GB)|
|Assignee:||Imperial Chemical Industries PLC (London, GB2)|
Patent Claim Types:|
see list of patent claims
|Compound; Process; Composition; Dosage form; Use;|
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|United Kingdom||8327256||Oct 12, 1983|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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