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Generated: November 23, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,659,516

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Summary for Patent: 4,659,516

Title: Steroid derivatives
Abstract:A steroid derivative of the formula: wherein ST is a 7.alpha.-linked steroid nucleus of the general formula: ##STR1## wherein the double bond(s) between carbon atoms 6 and 7 and/or carbon atoms 8 and 9 are optional; wherein the aromatic ring A may optionally bear one or two halogen or alkyl substituents; wherein R.sup.3 is hydrogen, alkyl, or acyl; wherein R.sup.16 is hydrogen, alkyl or hydroxy; wherein either R.sup.17 is hydroxy or acyloxy and R.sup.27 is hydrogen, alkyl, alkenyl or alkynyl, or R.sup.17 and R.sup.27 together form oxo (.dbd.O); wherein R.sup.18 is alkyl; wherein A is alkylene, alkenylene or alkynylene optionally fluorinated and optionally interrupted by --O--, --S--, --SO--, --SO.sub.2 --, --CO--, --NR--, --NRCO--, --CONR--, --COO--, --OCO-- or phenylene, wherein R is hydrogen or alkyl; wherein R.sup.1 is hydrogen, alkyl, alkenyl, cycloalkyl, halogenoalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl, arylalkyl, or dialkylaminoalkyl, or R.sup.1 is joined to R.sup.2 as defined below; and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR2## --SO.sub.2 NR.sup.2 -- or --CO--; or, when R.sup.1 is not hydrogen, is --O--, --NR.sup.2 --, --(NO)R.sup.2 --, --(PO)R.sup.2 --, --NR.sup.12 COO--; --NR.sup.12 SO.sub.2 --, --S--, --SO-- or --SO.sub.2 --; wherein R.sup.2 is hydrogen or alkyl or R.sup.1 and R.sup.2 together form alkylene or halogenoalkylene; wherein R.sup.12 is hydrogen or alkyl and wherein R.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.
Inventor(s): Bowler; Jean (Sandbach, GB), Tait; Brian S. (Macclesfield, GB)
Assignee: Imperial Chemical Industries PLC (London, GB2)
Application Number:06/656,466
Patent Claim Types:
see list of patent claims
Compound; Process; Composition; Dosage form; Use;

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Foreign Priority and PCT Information for Patent: 4,659,516

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8327256Oct 12, 1983

International Patent Family for Patent: 4,659,516

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria35814► Subscribe
Germany122004000011► Subscribe
Germany3472792► Subscribe
European Patent Office0138504► SubscribeSPC/GB04/009United Kingdom► Subscribe
European Patent Office0138504► Subscribe91068Luxembourg► Subscribe
European Patent Office0138504► Subscribe300158Netherlands► Subscribe
European Patent Office0138504► Subscribe2004C/004Belgium► Subscribe
United Kingdom8327256► Subscribe
JapanH0216759► Subscribe
JapanS6097995► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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Serving leading biopharmaceutical companies globally:

Covington
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Fish and Richardson
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