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Last Updated: December 12, 2025

Claims for Patent: 4,659,516

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Summary for Patent: 4,659,516

Title:	Steroid derivatives
Abstract:	A steroid derivative of the formula: ST--A--X--R.sup.1 wherein ST is a 7α-linked steroid nucleus of the general formula: ##STR1## wherein the double bond(s) between carbon atoms 6 and 7 and/or carbon atoms 8 and 9 are optional; wherein the aromatic ring A may optionally bear one or two halogen or alkyl substituents; wherein R3 is hydrogen, alkyl, or acyl; wherein R16 is hydrogen, alkyl or hydroxy; wherein either R17 is hydroxy or acyloxy and R27 is hydrogen, alkyl, alkenyl or alkynyl, or R17 and R27 together form oxo (═O); wherein R18 is alkyl; wherein A is alkylene, alkenylene or alkynylene optionally fluorinated and optionally interrupted by --O--, --S--, --SO--, --SO2 --, --CO--, --NR--, --NRCO--, --CONR--, --COO--, --OCO-- or phenylene, wherein R is hydrogen or alkyl; wherein R1 is hydrogen, alkyl, alkenyl, cycloalkyl, halogenoalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl, arylalkyl, or dialkylaminoalkyl, or R1 is joined to R2 as defined below; and wherein X is --CONR2 --, --CSNR2 --, --NR12 CO--, --NR12 CS--, --NR12 CONR2 --, ##STR2## --SO2 NR2 -- or --CO--; or, when R1 is not hydrogen, is --O--, --NR2 --, --(NO)R2 --, --(PO)R2 --, --NR12 COO--; --NR12 SO2 --, --S--, --SO-- or --SO2 --; wherein R2 is hydrogen or alkyl or R1 and R2 together form alkylene or halogenoalkylene; wherein R12 is hydrogen or alkyl and wherein R22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.
Inventor(s):	Jean Bowler, Brian S. Tait
Assignee:	AstraZeneca UK Ltd, Syngenta Ltd
Application Number:	US06/656,466
Patent Claims:

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