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|Title:||Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides|
|Abstract:||Stable neutral-lipophilic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclidic imaging agents are formed by complexing technetium-99m pertechnetate with alkylene amine oximes (viz. propylene amine oxime) in aqueous solutions under reducing conditions. The complexes have a zero charge, contain an O--H--O ring closure bond, and are sufficiently stable for parental administration in imaging by scintillation scanning. Substituents can be attached to the C.sub.2 to C.sub.4 alkylene carbon backbone of the tetradentate amine oxime ligands to structurally modify them and produce a variety of Tc-99m-radiopharmaceuticals with specific body imaging applications.|
|Inventor(s):||Troutner; David E. (Columbia, MO), Volkert; Wynn A. (Columbia, MO)|
|Assignee:||Curators of the University of Missouri (Columbia, MO)|
Patent Claim Types:|
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|Formulation; Dosage form;|
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