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Generated: August 20, 2017

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Title: Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
Abstract:Stable neutral-lipophilic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclidic imaging agents are formed by complexing technetium-99m pertechnetate with alkylene amine oximes (viz. propylene amine oxime) in aqueous solutions under reducing conditions. The complexes have a zero charge, contain an O--H--O ring closure bond, and are sufficiently stable for parental administration in imaging by scintillation scanning. Substituents can be attached to the C.sub.2 to C.sub.4 alkylene carbon backbone of the tetradentate amine oxime ligands to structurally modify them and produce a variety of Tc-99m-radiopharmaceuticals with specific body imaging applications.
Inventor(s): Troutner; David E. (Columbia, MO), Volkert; Wynn A. (Columbia, MO)
Assignee: Curators of the University of Missouri (Columbia, MO)
Application Number:06/488,184
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Formulation; Dosage form;

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Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia2711884► Subscribe
Australia564636► Subscribe
Canada1231715► Subscribe
Czechoslovakia271306► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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