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Last Updated: April 18, 2024

Details for Patent: 4,615,876

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Summary for Patent: 4,615,876

Title:	Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
Abstract:	Stable neutral-lipophilic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclidic imaging agents are formed by complexing technetium-99m pertechnetate with alkylene amine oximes (viz. propylene amine oxime) in aqueous solutions under reducing conditions. The complexes have a zero charge, contain an O--H--O ring closure bond, and are sufficiently stable for parental administration in imaging by scintillation scanning. Substituents can be attached to the C.sub.2 to C.sub.4 alkylene carbon backbone of the tetradentate amine oxime ligands to structurally modify them and produce a variety of Tc-99m-radiopharmaceuticals with specific body imaging applications.
Inventor(s):	Troutner; David E. (Columbia, MO), Volkert; Wynn A. (Columbia, MO)
Assignee:	Curators of the University of Missouri (Columbia, MO)
Application Number:	06/488,184
Patent Claim Types: see list of patent claims	Formulation; Dosage form;

Drugs Protected by US Patent 4,615,876

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	2711884	⤷ Try a Trial
Australia	564636	⤷ Try a Trial
Canada	1231715	⤷ Try a Trial
Czechoslovakia	271306	⤷ Try a Trial
Czechoslovakia	8403030	⤷ Try a Trial
Germany	123504	⤷ Try a Trial
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