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Serving leading biopharmaceutical companies globally:

Chinese Patent Office
Queensland Health

Generated: December 18, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,603,146

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Summary for Patent: 4,603,146

Title: Methods for retarding the effects of aging of the skin
Abstract:Various effects of aging of skin due to impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and deterioration of small blood vessels in the dermis of the skin are retarded by applying topically to the epidermis in a maintenance therapy program effective amounts of vitamin A acid (tretinoin) such that epithelial growths are substantially reduced and prevented and the skin substantially regains and maintains its firmness, turgor and elasticity. Moreover, with persistent treatment dermal blood cells and vessels increase and the epidermis and dermis thicken, resulting in improved ability of the skin to sense, resist and recover from irritation or injury. Further, hyperpigmentation, lines and wrinkles due to aging are reduced and prevented. The treatment is particularly useful for human facial skin and preferably applied in amounts insufficient to cause excessive irritation.
Inventor(s): Kligman; Albert M. (Philadelphia, PA)
Application Number:06/759,505
Patent Claim Types:
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Use; Composition;

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International Patent Family for Patent: 4,603,146

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia5289686► Subscribe
Australia598454► Subscribe
Australia599135► Subscribe
Australia7804687► Subscribe
Canada1303996► Subscribe
Canada1324962► Subscribe
Germany3440831► Subscribe
Germany3562543► Subscribe
Denmark140388► Subscribe
Denmark155482► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Queensland Health
Cantor Fitzgerald

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