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Claims for Patent: 4,603,146

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Claims for Patent: 4,603,146

Title: Methods for retarding the effects of aging of the skin
Abstract:Various effects of aging of skin due to impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and deterioration of small blood vessels in the dermis of the skin are retarded by applying topically to the epidermis in a maintenance therapy program effective amounts of vitamin A acid (tretinoin) such that epithelial growths are substantially reduced and prevented and the skin substantially regains and maintains its firmness, turgor and elasticity. Moreover, with persistent treatment dermal blood cells and vessels increase and the epidermis and dermis thicken, resulting in improved ability of the skin to sense, resist and recover from irritation or injury. Further, hyperpigmentation, lines and wrinkles due to aging are reduced and prevented. The treatment is particularly useful for human facial skin and preferably applied in amounts insufficient to cause excessive irritation.
Inventor(s): Kligman; Albert M. (Philadelphia, PA)
Assignee:
Application Number:06/759,505
Patent Claims: 1. A method for retarding and reversing the loss of collagen fibers, abnormal changes in elastic fibers, the deterioration of small blood vessels, and the formation of abnormal epithelial growths in sundamaged human skin, comprising applying topically to the epidermis of the skin a composition comprising effective amounts of vitamin A acid in an emollient vehicle in a program of maintenance therapy, whereby the skin substantially regains and maintains its firmness, turgor and elasticity during said therapy, said composition and amounts of vitamin A acid being selected so as to provide a sub-irritating dose of vitamin A acid.

2. A method according to claim 1 wherein said skin is human facial skin.
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