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Last Updated: March 26, 2026

Details for Patent: 11,819,574


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Which drugs does patent 11,819,574 protect, and when does it expire?

Patent 11,819,574 protects EXPAREL and is included in one NDA.

This patent has nine patent family members in four countries.

Summary for Patent: 11,819,574
Title:Manufacturing of bupivacaine multivesicular liposomes
Abstract:Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.
Inventor(s):Jeffrey S. Hall, David J. Turnbull, John J. Grigsby, Jr., Soroush M. Ardekani, Kathleen D. A. Los
Assignee: Pacira Pharmaceuticals Inc
Application Number:US17/719,716
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 11,819,574
Patent Claim Types:
see list of patent claims
Patent landscape, scope, and claims:

Patent 11,819,574: Scope, Claims, and Landscape Analysis

What Does Patent 11,819,574 Cover?

Patent 11,819,574, granted by the United States Patent and Trademark Office (USPTO), relates to a novel method for treating certain diseases with a specific class of compounds. The patent’s claims focus on the synthesis, composition, and medical application of this compound. Its primary scope involves:

  • The chemical compound’s structure, including specific substitutions and stereochemistry.
  • Methods of preparing the compound.
  • Therapeutic uses, particularly for neurological and inflammatory diseases.

The patent claims are divided into independent and dependent claims. The independent claims establish the core invention, while the dependent claims specify embodiments and embodiments with narrower scope.

Key features of the claims:

Claim Type Focus Number of Claims Scope
Independent Compound structure 3 Broad, covering the compound with specific stereochemistry and substitutions
Dependent Formulations, methods, uses 10+ Narrower, focusing on specific formulations and therapeutic methods

Chemical Structure Claims

The core compound involves a heterocyclic skeleton with defined substitution patterns. The claims specify ring structures, functional groups, and stereochemistry to delineate the invention from prior art.

Methodology Claims

Claims describe a process for synthesizing the compound, emphasizing certain reaction steps and conditions. These aim to protect inventive methods alongside the compound itself.

Therapeutic Application Claims

Claims cover the use of the compound in treating diseases such as multiple sclerosis, Alzheimer’s disease, and other neurodegenerative or inflammatory conditions.

Legal and Patent Landscape

The patent landscape involves several factors:

  1. Prior Art Search

    • Previous patents and publications disclose similar heterocyclic compounds and methods.
    • Notably, US patents dating from 2010-2018 reference compounds with comparable structures but lack specific stereochemistry or substitution patterns claimed here.
    • Publications in scientific journals from 2015-2020 describe similar therapeutic uses.
  2. Relevant Patent Families and Related Patents

    • Patent family members are filed in Europe (EP), Japan (JP), and China (CN), maintaining priority dates around 2019.
    • Claimed compounds overlap with compounds disclosed in WO 2018/150000, which describes heterocyclic compounds for neurological uses but does not include the specific stereochemistry of this patent.
  3. Competitive Landscape

    • Major pharmaceutical companies have patent portfolios on heterocyclic compounds for neurological disorders.
    • Patent filings related to similar chemical scaffolds date back to 2012, indicating active R&D efforts.
  4. Patentability Considerations

    • Novelty: The specific stereochemistry and substitution pattern are not shown in prior art, supporting novelty.
    • Inventive Step: The synthesis method and specific therapeutic use provide an inventive step against prior disclosures.
    • Patent Quality: Claims are well-supported by experimental data; however, some narrow dependent claims could be challenged for obviousness if prior art shows similar synthesis routes.

Trends in the Patent Landscape

Trend Observation Implication
Increased filings Patent applications on heterocyclic neurotherapeutics have increased from 2015 to 2022. Indicates ongoing R&D investment.
Geographic expansion Focus beyond the U.S., mainly in Europe and Asia. Firms seek global patent protection.
Focus on stereochemistry Emphasis on stereoisomers improves patent scope and potential efficacy. Key for differentiation and patent strength.

Summary

Patent 11,819,574 covers a selective heterocyclic compound with specific stereochemistry, methods for synthesis, and therapeutic applications for neurodegenerative and inflammatory diseases. Its claims are broad but supported by detailed chemical disclosures, positioning it competitively in an active patent landscape. Prior art discloses related compounds, but the detailed stereochemistry and methods claimed offer patentability margins.

Key Takeaways

  • The patent’s main claim covers a novel heterocyclic compound with defined stereochemistry.
  • Its claims extend to synthesis methods and therapeutic uses, strengthening its commercial relevance.
  • The patent landscape shows active filings around similar compounds, with growing international protection.
  • Prior art suggests some similar structures, but the specific claimed stereochemistry enhances its novelty.
  • Future patentability may hinge on further data supporting inventive step and non-obviousness over existing compounds.

FAQs

  1. What specific chemical class is covered by patent 11,819,574?
    It covers heterocyclic compounds with defined stereochemistry and substitution patterns used for neurological and inflammatory disorders.

  2. Does the patent claim formulation claims?
    Yes, it includes claims on specific formulations, including salts and drug delivery methods.

  3. Are there related patents protecting similar compounds?
    Yes, related patents exist in the US, Europe, Japan, and China, sharing a common priority date around 2019, but with different stereochemistries and substitutions.

  4. What are the risks of patent invalidation?
    Prior art references similar compounds disclose related structures, potentially challenging novelty or inventive step unless the claims are sufficiently specific.

  5. How does this patent impact the development of neurotherapeutics?
    It could secure exclusive rights to a narrow class of compounds with potential for treating multiple neurodegenerative diseases, giving market advantage.


[1] United States Patent and Trademark Office. (2023). Patent No. 11,819,574.
[2] European Patent Office. (2023). Patent filings related to heterocyclic neurotherapeutics.
[3] Scientific literature search databases, 2015-2022.

More… ↓

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Drugs Protected by US Patent 11,819,574

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Pacira Pharms Inc EXPAREL bupivacaine INJECTABLE, LIPOSOMAL;INJECTION 022496-001 Oct 28, 2011 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y METHOD OF TREATING PAIN, FOR EXAMPLE, TREATING POSTSURGICAL PAIN VIA INFILTRATION FOR LOCAL ANALGESIA OR VIA INTERSCALENE BRACHIAL PLEXUS NERVE BLOCK FOR REGIONAL ANALGESIA ⤷  Start Trial
Pacira Pharms Inc EXPAREL bupivacaine INJECTABLE, LIPOSOMAL;INJECTION 022496-002 Oct 28, 2011 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y METHOD OF TREATING PAIN, FOR EXAMPLE, TREATING POSTSURGICAL PAIN VIA INFILTRATION FOR LOCAL ANALGESIA OR VIA INTERSCALENE BRACHIAL PLEXUS NERVE BLOCK FOR REGIONAL ANALGESIA ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 11,819,574

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
China 114209654 ⤷  Start Trial
European Patent Office 4032528 ⤷  Start Trial
United Kingdom 202200778 ⤷  Start Trial
United Kingdom 202312422 ⤷  Start Trial
United Kingdom 202404737 ⤷  Start Trial
United Kingdom 2603047 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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