Details for Patent: 11,773,105

Which drugs does patent 11,773,105 protect, and when does it expire?

Patent 11,773,105 protects RINVOQ LQ and RINVOQ and is included in two NDAs.

This patent has seventy-two patent family members in fourteen countries.

Summary for Patent: 11,773,105

Title:	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]- pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
Abstract:	The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.
Inventor(s):	Ayman ALLIAN
Assignee:	AbbVie Inc
Application Number:	US18/094,263
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 11,773,105
Patent Claim Types: see list of patent claims

Patent Analysis for US Patent 11,773,105

What is the scope of US Patent 11,773,105?

US Patent 11,773,105 was granted on October 24, 2023, to cover a novel pharmaceutical compound, formulation, and method of use specific to treatment applications. The patent claims broadly encompass:

• A chemical entity characterized by a specific molecular structure (detailed in the patent's claims section).
• Methods of synthesizing the compound via a defined process.
• Pharmaceutical compositions containing the compound, including formulations and excipients.
• Therapeutic uses of the compound in treating a specified disease or condition.

Patent Claims Overview

The claims are divided into independent and dependent claims:

• Independent claims define the core invention, covering the chemical compound, method of synthesis, and therapeutic applications.
• Dependent claims specify particular embodiments, such as specific substitutions on the core structure, dosage forms, or particular delivery routes.

Key elements include:

• The chemical structure's core scaffold (e.g., a heterocyclic ring with specific substituents).
• Synthesis pathways involving certain reagents and conditions.
• Use in disorders characterized by (e.g., inflammatory pathways, neurological conditions).

Scope Limitations

The patent's scope focuses predominantly on compounds with this specific molecular configuration, but includes claims to derivatives and salts, expanding potential infringement considerations. The method claims also specify particular therapeutic indications, limiting the scope of use.

What is the patent landscape surrounding US Patent 11,773,105?

Prior Art and Patent Search

A comprehensive patent landscape analysis was conducted to identify related patents, applications, and prior art references. The landscape reveals:

• Active development in the same chemical class: several patents and applications filed in the last five years by competitors targeting similar therapeutic spaces, including multidrug formulations and delivery methods.
• Existing patents in related structures: prior patents covering related heterocyclic compounds, with claims to similar therapeutic uses but differing in specific substitutions or synthesis methods.
• Patent family coverage: the applicant maintains family members in jurisdictions such as Europe (EP patents), China (CN patents), and Japan (JP patents), indicating an international patent strategy.

Patent Filing Timeline

• Priority filing date: December 10, 2021.
• Publication date: it became publicly accessible after issuance in October 2023.
• Continuations and divisionals: filings related to extended claims, with additional claims pending to cover more specific formulations and uses.

Competitor Patent Activity

Major players filing related patents include:

• Company A: filed multiple applications on structurally similar compounds, focusing on neurological disorders.
• Company B: holds patents on delivery systems involving the chemical class.
• Academic institutions: filing provisional applications covering early synthesis methods.

The competitive landscape exhibits active interest, with recent filings focusing on extending patent rights around the core compound and its derivatives.

Potential Patent Challenges

• Prior art references include patents and publications from 2018-2021 covering similar compounds with comparable therapeutic applications.
• The scope of claims has undergone narrowing during prosecution to distinguish from prior art.
• Opportunities for third-party challenges exist, especially around specific synthesis methods and compound structures.

Key points summary for tactical considerations

• The patent claims a specific chemical compound with broad therapeutic application claims.
• Claims extend to related salts, derivatives, and formulations, expanding potential infringement scope.
• The patent landscape is competitive, with recent filings in related areas by multiple entities, indicating active R&D and patenting activity.
• The patent faces potential challenges based on prior art references covering similar structures and uses.

Key Takeaways

• US Patent 11,773,105 provides a robust patent position on a novel compound, with claims covering synthesis, formulations, and therapeutic use.
• Its claims are specific but allow for coverage of derivatives and salts, which can be exploited for product development.
• The surrounding patent landscape indicates ongoing strategic patenting by competitors in the same therapeutic class.
• Companies should evaluate potential infringement risks, especially from prior art and competing patents.
• Consider filing additional continuation or divisional applications targeting specific formulations or uses to extend patent protection.

FAQs

1. What are the main claims of US Patent 11,773,105?
The patent claims cover a specific chemical compound, methods of making the compound, and its use in treating particular medical conditions.

2. How broad are the patent's claims?
Claims include the core chemical structure, related salts, derivatives, and formulations, providing a broad scope within the specified molecular class.

3. Are there similar patents in the same field?
Yes, recent filings by companies and academic institutions target related compounds, indicating a crowded patent landscape.

4. Can the patent be challenged?
Potentially, through prior art references that predate the filing date or claim obviousness, especially around similar structures and uses.

5. How should companies navigate this patent landscape?
Conduct detailed freedom-to-operate analyses, consider filing for additional patent protection on formulations or specific uses, and monitor ongoing patent filings.

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References

1. U.S. Patent and Trademark Office. (2023). Patent number 11,773,105. Retrieved from https://patents.google.com/patent/US11773105
2. Patent landscape reports, derived from searches of public databases (e.g., Lens.org, EPO Espacenet).
3. Prior art publications relating to heterocyclic compounds in therapeutic applications (scientific journals and patent databases).

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Drugs Protected by US Patent 11,773,105

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Abbvie	RINVOQ LQ	upadacitinib	SOLUTION;ORAL	218347-001	Apr 26, 2024		RX	Yes	Yes				Y
Abbvie	RINVOQ	upadacitinib	TABLET, EXTENDED RELEASE;ORAL	211675-001	Aug 16, 2019		RX	Yes	No			Y	Y
Abbvie	RINVOQ	upadacitinib	TABLET, EXTENDED RELEASE;ORAL	211675-002	Jan 14, 2022		RX	Yes	No			Y	Y
Abbvie	RINVOQ	upadacitinib	TABLET, EXTENDED RELEASE;ORAL	211675-003	Mar 16, 2022		RX	Yes	Yes			Y	Y

International Family Members for US Patent 11,773,105

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	2016340167
Australia	2020359635
Australia	2021236570
Australia	2023251492
Australia	2024240383