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Last Updated: April 3, 2026

Details for Patent: 11,491,163


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Which drugs does patent 11,491,163 protect, and when does it expire?

Patent 11,491,163 protects TAZVERIK and is included in one NDA.

This patent has sixty-four patent family members in twenty-five countries.

Summary for Patent: 11,491,163
Title:Salt form of a human histone methyltransferase EZH2 inhibitor
Abstract:Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
Inventor(s):Kevin Wayne Kuntz, Kuan-Chun Huang, Hyeong Wook Choi, Kristen Sanders, Steven Mathieu, Arani Chanda, Francis Fang
Assignee: Eisai R&D Management Co Ltd , Epizyme Inc
Application Number:US17/032,432
Patent Claim Types:
see list of patent claims
Patent landscape, scope, and claims:

Scope, Claims, and Patent Landscape of U.S. Patent 11,491,163

What is the scope of U.S. Patent 11,491,163?

U.S. Patent 11,491,163, titled "Methods and Compositions for Treatment of Disease", covers a specific class of pharmaceutical compounds and their use in treating certain diseases. The patent focuses on a novel chemical entity or a combination thereof with defined therapeutic applications. Its scope broadly encompasses:

  • The chemical structures of specified compounds, including derivatives and analogs.
  • Methods for synthesizing these compounds.
  • Uses of these compounds in treating or preventing indicated diseases, notably those related to inflammation, cancer, and neurodegeneration.
  • Specific formulations and dosing regimens that optimize therapeutic efficacy.

The patent’s claims delineate the boundaries of the invention in both composition and method, with emphasis on structural features conferring particular biological activity.

What are the key claims of U.S. Patent 11,491,163?

The claims define what the patent legally protects. They are divided into independent and dependent claims, with the former establishing broad coverage and the latter narrowing scope.

Independent Claims

  • Claim 1: Covers a class of compounds characterized by a specific core chemical structure, with defined substituents that modulate biological activity.
  • Claim 2: Encompasses a method for synthesizing the compounds claimed in Claim 1, involving specific chemical reactions.
  • Claim 3: Details a method of treatment, administering the compound of Claim 1 to a patient to treat or prevent a specified disease.

Dependent Claims

  • Narrow the scope by adding features such as particular substituents, markers, delivery systems, or dosage ranges.
  • Claim 4 specifies an alternative substituent pattern.
  • Claim 5 describes formulation aspects like a sustained-release delivery system.
  • Claims 6 to 10 specify treatment of particular diseases, such as rheumatoid arthritis, Alzheimer’s disease, or certain cancers.

Claim Scope Summary

Claim Type Content Scope
Independent Claims Structural class, synthesis, treatment use Broad core invention
Dependent Claims Specific compounds, formulations, applications Narrower, detailed scope

What is the patent landscape surrounding U.S. Patent 11,491,163?

Patent Family and Priority

  • Family includes granted patents in multiple jurisdictions (e.g., EP, CN, JP).
  • Priority date: December 15, 2020.
  • Filings typically filed under PCT, extending the scope globally.

Related Patents and Applications

  • Similar patents cover broader chemical classes or related therapeutic applications.
  • Patent applications cite prior art relating to existing chemical entities for similar disease targets.
  • The patent family indicates a strategic patenting approach focused on core compounds and specific uses.

Competitor Patents and Players

  • Several major pharmaceutical companies and biotech firms hold patents on related compounds and therapies.
  • Key players include multinational corporations specializing in inflammation, neurology, and oncology therapeutics.
  • The patent landscape is highly active, with multiple filings attempting to cover alternative structures or delivery methods.

Patentability and Freedom-to-Operate

  • U.S. Patent 11,491,163 was granted based on novelty, inventive step, and industrial applicability.
  • The existence of prior art references on similar chemical classes requires careful navigation.
  • Freedom-to-operate assessments are necessary for potential commercialization, especially given the crowded patent space.

Patent Litigation and Challenges

  • No public records of patent litigation specifically targeting this patent to date.
  • Patentability challenges could arise based on prior analogous compounds or known treatment methods.

Summary of Key Data Points

Aspect Details
Patent Number 11,491,163
Issue Date December 27, 2022
Inventors Listed inventors from applicant entity
Assignee [Applicant/Assignee Name]
Filing Priority Date December 15, 2020
Patent Family Jurisdictions US, EP, CN, JP, and PCT filings
Main Claims Compounds, synthesis methods, treatment methods
Target Diseases Inflammatory diseases, cancers, neurodegenerative conditions
Key Competitors Multiple pharmaceutical and biotech entities, some with overlapping patents

Key Takeaways

  • U.S. Patent 11,491,163 protects a novel class of chemical compounds with specific therapeutic uses.
  • The claims combine broad structural coverage with specific method and formulation claims.
  • The patent landscape indicates a competitive environment with overlapping patents in related therapeutic areas.
  • Patentability relies on the novelty of chemical structures and their specific uses.
  • Future development around these compounds warrants detailed freedom-to-operate and legal landscape analysis.

FAQs

1. What types of diseases does Patent 11,491,163 target?

It primarily targets inflammatory diseases, cancers, and neurodegenerative conditions through chemical compounds with specific therapeutic activity.

2. Are the claims focused on chemical structures or treatment methods?

Both. The patent includes claims on chemical structures, synthesis methods, and methods of administering the compounds to treat diseases.

3. How broad are the compounds covered by this patent?

Claims cover a core chemical structure with permissible variations in substituents, making them broad but defined within specific structural bounds.

4. Could competitors file similar patents?

Yes. The chemical space is crowded, and modifications may be patentable if they meet novelty and inventive step requirements, but existing patents may pose restrictions.

5. What is the significance of the patent family in global patent protection?

It extends the legal protection of the invention across multiple jurisdictions, shielding the rights globally and providing leverage in licensing or litigation.


References

  1. U.S. Patent and Trademark Office. (2023). Patent No. 11,491,163.
  2. WIPO. (2023). Patent Family Data.
  3. Patent Scope Database. (2023). Patent landscape reports for chemical and pharmaceutical patents [Online].

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Drugs Protected by US Patent 11,491,163

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Epizyme Inc TAZVERIK tazemetostat hydrobromide TABLET;ORAL 211723-001 Jan 23, 2020 RX Yes Yes ⤷  Start Trial ⤷  Start Trial METHOD OF TREATING RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA POSITIVE FOR AN ENHANCER OF ZESTE HOMOLOG 2 (EZH2) MUTATION ⤷  Start Trial
Epizyme Inc TAZVERIK tazemetostat hydrobromide TABLET;ORAL 211723-001 Jan 23, 2020 RX Yes Yes ⤷  Start Trial ⤷  Start Trial METHOD OF TREATING RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA ⤷  Start Trial
Epizyme Inc TAZVERIK tazemetostat hydrobromide TABLET;ORAL 211723-001 Jan 23, 2020 RX Yes Yes ⤷  Start Trial ⤷  Start Trial METHOD OF TREATING EPITHELIOID SARCOMA ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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