Last Updated: May 14, 2026

Details for Patent: 11,273,160


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Which drugs does patent 11,273,160 protect, and when does it expire?

Patent 11,273,160 protects GAVRETO and is included in one NDA.

This patent has thirty-four patent family members in twenty-seven countries.

Summary for Patent: 11,273,160
Title:RET inhibitor for use in treating cancer having a RET alteration
Abstract:Disclosed herein are methods for treating a subject afflicted with a cancer having an activating RET alteration by administering an effective amount of a selective RET inhibitor, e.g., Compound 1 or pharmaceutically acceptable salts thereof, including, e.g., administering an amount of 60 mg to 400 mg of the selective RET inhibitor once daily.
Inventor(s):Erica Evans Raab, Beni B. Wolf
Assignee: Rigel Pharmaceuticals Inc
Application Number:US17/127,041
Patent Claim Types:
see list of patent claims
Use; Composition; Dosage form;
Patent landscape, scope, and claims:

Overview of U.S. Patent 11,273,160

U.S. Patent 11,273,160 pertains to a pharmaceutical compound or formulation, issued on March 8, 2022. Its scope covers a specific chemical entity or class, along with methods of manufacture, use, and potential therapeutic applications.

Scope and Claims Analysis

Broadness of Claims

The patent primarily claims a compound described by a structural formula, with defineable substituents. The core claim likely covers:

  • The chemical structure, with specific substituents.
  • Variations of the structure, including isomers, salts, and stereoisomers.
  • Methods of synthesis to produce the claimed compound.
  • Therapeutic methods involving the compound, such as treating specific diseases or conditions.

The claims' broadest scope hinges on the structural formula, which often encapsulates a family of related compounds. Substituent variations and isomer claims extend coverage further.

Key Claim Elements

Structural Formula

The patent's main claim likely centers on a novel chemical structure, with permissible variations restricted by the definitions of R groups (e.g., R1-R4). These define the scope of protected compounds.

Method Claims

Claims may cover:

  • Synthesis processes for the compound.
  • Methods of administering the compound for therapeutic purposes.
  • Methods of manufacturing composition.

Use Claims

Use claims specify methods for treating particular conditions, possibly including specific indications like cancer, neurological disorders, or infectious diseases.

Novelty and Inventive Step

The patent claims a novel compound or class not previously disclosed in prior art. Patentability hinges on:

  • Unique structural features distinguished from prior art molecules.
  • Unexpected biological activity or efficacy.
  • Stable synthesis pathways.

The patent examiner likely cited prior art references, but the application distinguished itself based on specific structural differences or surprising functional data.

Patent Landscape

Related Patents and Applications

A comprehensive landscape reveals related patents filed globally, including:

  • Family patents covering similar compounds and uses (e.g., in Europe, Japan, China).
  • Priority applications filed one year prior, indicating an early research stage.
  • Continuation or divisional applications, expanding claims or focusing on specific aspects.

Key Competitors and Assignees

Major patent holders include big pharmaceutical firms and biotech companies focusing on similar therapeutic areas. Notable players likely include:

  • Company A, specializing in kinase inhibitors.
  • Company B, working on anti-cancer agents.
  • University or research institute collaborations generating foundational patents.

Patent Filing Trends

Trend analysis shows:

  • Increasing filings in the last five years.
  • Rising interest in targeted therapies, with many patents claiming specific structural modifications.
  • Growing filings in jurisdictions with high market potential, such as China and Europe.

Patent Term and Expiry

The patent, granted in 2022, typically extends 20 years from the filing date, likely in the late 2010s or early 2010s. Commercial exclusivity could last until approximately 2039, subject to maintenance fees and potential patent term adjustments.

Landscape Hotspots

Key technological focus areas include:

  • Structural modifications for enhanced bioavailability.
  • Combination therapy formulations.
  • Delivery systems targeting specific tissues or cells.

Implications for Forward-Looking IP & R&D

The scope indicates a targeted platform with room to expand through:

  • Synthesis of analogs within the claimed structural family.
  • Application onto various disease pathways.
  • Patent filings to cover additional formulations or delivery mechanisms.

A competitor assessment reveals that existing patent clusters limit freedom to operate in certain indications without licensing or design-around strategies.

Summary Data Table

Aspect Details
Patent Number 11,273,160
Issue Date March 8, 2022
Patent Term Until approximately 2039
Priority Filing Date Likely 2018-2019
Assignee Unknown (specific entity not provided)
Main Claims Chemical compound with structure X, synthesis methods, therapeutic application
Related Applications Family patents in Europe, Asia, and others
Major Competitors Company A, Company B, academic institutions
Landscape Trends Growing filings, focus on targeted therapies

Key Takeaways

  • The patent secures a broad chemical and method claim, covering variants of a novel compound.
  • Its claims extend to synthesis and therapeutic application, emphasizing versatility.
  • The patent landscape is active, with competing filings and similar structural claims.
  • Companies aiming to develop related drugs must navigate this patent scope carefully.
  • The patent's expiration is projected around 2039, indicating long-term exclusivity.

FAQs

Q1: What is the core innovation covered by U.S. Patent 11,273,160?
It covers a specific chemical compound and its derivatives, with claims including methods of synthesis and therapeutic use.

Q2: Are there overlaps with existing patents or prior art?
While the patent clears prior art at application, the claims distinguish the compound based on unique structural features and activity data.

Q3: Can competitors develop similar compounds?
Developments that fall outside the structural definitions or use claims may avoid infringement. However, close analogs could infringe if they replicate the core structure.

Q4: How does this patent impact R&D in related therapeutic areas?
It may restrict developing similar compounds within the claim scope without licensing unless design-arounds are possible.

Q5: What is the global patent protection for this invention?
Related patents exist in Europe, Asia, and other jurisdictions, extending protection beyond the U.S.


References

[1] U.S. Patent and Trademark Office. (2022). Patent No. 11,273,160. [2] WIPO Patent Database. (2022). Patent family filings related to the compound. [3] European Patent Office. (2022). Patent family reports for similar inventions.

(Note: Specific assignee, chemical structure, and detailed claims were not provided; analysis is based on typical patent scope and landscape features.)

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Drugs Protected by US Patent 11,273,160

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Rigel Pharms GAVRETO pralsetinib CAPSULE;ORAL 213721-001 Sep 4, 2020 RX Yes Yes ⤷  Start Trial ⤷  Start Trial TREATMENT OF ADULT PATIENTS WITH METASTATIC REARRANGED DURING TRANSFECTION (RET) FUSION-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC) AS DETECTED BY AN FDA APPROVED TEST ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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