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Last Updated: April 19, 2024

Details for Patent: 10,631,746


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Summary for Patent: 10,631,746
Title:Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
Abstract: A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.
Inventor(s): Flower; Robert W. (Hunt Valley, MD), Stead; Robert Anthony (Vancouver, CA), Bailey; Arthur E. (North Vancouver, CA)
Assignee: Novadaq Technologies ULC (Burnaby, CA)
Application Number:15/517,895
Patent Claim Types:
see list of patent claims
Use; Process; Device;

Drugs Protected by US Patent 10,631,746

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Novadaq Tech SPY AGENT GREEN KIT indocyanine green POWDER;INTRAVENOUS, INTERSTITIAL 211580-001 Nov 21, 2018 RX Yes Yes ⤷  Try a Trial ⤷  Try a Trial Y MEASURING TIME-VARYING CHANGE IN BLOOD IN A TISSUE VOLUME USING MODIFIED BEER-LAMBERT LAW IN VASCULAR, GASTROINTESTINAL, ORGAN TRANSPLANT, AND PLASTIC, MICRO- AND RECONSTRUCTIVE, INCLUDING MINIMALLY INVASIVE, SURGERY ⤷  Try a Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 10,631,746

PCT Information
PCT FiledOctober 09, 2014PCT Application Number:PCT/IB2014/065189
PCT Publication Date:April 14, 2016PCT Publication Number: WO2016/055837

International Family Members for US Patent 10,631,746

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2014408488 ⤷  Try a Trial
Australia 2019250179 ⤷  Try a Trial
Canada 2963450 ⤷  Try a Trial
China 107427247 ⤷  Try a Trial
European Patent Office 3203902 ⤷  Try a Trial
European Patent Office 3915467 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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