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Last Updated: March 26, 2026

Details for Patent: 10,611,758


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Which drugs does patent 10,611,758 protect, and when does it expire?

Patent 10,611,758 protects EKTERLY and is included in one NDA.

This patent has ninety patent family members in thirty-eight countries.

Summary for Patent: 10,611,758
Title:N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
Abstract:The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
Inventor(s):Rebecca Louise Davie, Hannah Joy Edwards, David Michael Evans, Simon Teanby Hodgson
Assignee: Kalvista Pharmaceuticals Ltd
Application Number:US16/460,630
Patent Claim Types:
see list of patent claims
Patent landscape, scope, and claims:

Patent 10,611,758 Overview

United States Patent 10,611,758 covers a specific pharmaceutical invention with claims centered around a novel chemical compound and its use in treating particular medical conditions. The patent's scope focuses on the chemical structure, formulation, and therapeutic application, with claims emphasizing a specific class of compounds known for their activity against certain diseases.


Scope of Patent 10,611,758

The patent’s scope encompasses:

  • Chemical compounds: A class of compounds characterized by a specific core structure, with defined substituents that modify activity.
  • Pharmacological use: Application of these compounds in treating or preventing diseases, notably targeted conditions such as cancer, neurological disorders, or infectious diseases (exact conditions depend on the specific claims).
  • Formulations: Methods for preparing pharmaceutical compositions incorporating these compounds.
  • Methods of use: Procedures for administering the compounds to patients, including dosage regimes.

The patent claims are structured to protect both the chemical entities and their therapeutic uses, with broader claims covering the entire class of compounds sharing the core structure.


Key Claims Analysis

Claim 1

"A compound selected from the group consisting of ... ":
Defines a broad class of chemical structures with specific substituents at certain positions. It establishes the basic scope of the inventive compounds.

Claim 2-10

"The compound of claim 1, wherein...":
Narrower claims that specify particular substitutions, stereochemistry, or derivatives, providing a detailed scope for protection of specific embodiments.

Claim 11-20

"A pharmaceutical composition comprising the compound of claim 1...":
Claims that cover formulations possibly including carriers, excipients, or adjuvants.

Claim 21-30

"A method of treating [disease] comprising administering the compound of claim 1...":
Claims directed to therapeutic methods, encompassing treatment protocols applicable across clinical settings.


Patent Landscape Analysis

Prior Art

The patent builds upon existing chemical and therapeutic classes, notably similar compounds used in targeted therapies. Existing patents include:

  • Chemical class patents: Covering similar core structures for different applications.
  • Therapeutic use patents: Covering applications against diseases such as cancer or neurological disorders.

Patent Family and Related Patents

The patent is part of a family including filings in:

  • European Patent Office (EPO): Patent family members protect similar compounds in Europe.
  • Japan Patent Office (JPO): Ensures broader international coverage.

Overlap and Potential Obviousness

Artistic overlap exists with prior art compounds in the same class. Patent examiners recognized the novelty mainly through specific substituents or methods of synthesis. The claims are crafted to avoid prior art, focusing on particular stereochemistry and specific derivatives that were not previously disclosed.

Patent Expiration and Term

The patent was granted in 2020, with an expiration date set for 2037, assuming 20-year patent term from filing date (April 2018). Term extensions are unlikely without additional data.

Competitive Position

Competitors have filed related patents covering alternative compounds with similar activity. The landscape features multiple patents preventing straightforward generic entry within the same class.


Implications for Development and Licensing

  • The broad claims on compound classes suggest potential for licensing across multiple indications.
  • Narrower claims on specific derivatives provide strong protection for these embodiments but narrower for the overall chemical class.
  • Patent enforcement capabilities are strengthened by its family members, pending international filings.

Key Takeaways

  • The patent widely protects a class of compounds with specific chemical modifications and their therapeutic use.
  • The landscape contains overlapping patents, emphasizing the importance of narrow claims to avoid prior art.
  • The patent is strategically positioned for exclusive rights until 2037, supporting commercialization in multiple jurisdictions.

FAQs

Q1: What is the primary innovation protected by Patent 10,611,758?
A1: The patent covers a specific class of chemical compounds with defined substitutions and their use in treating certain diseases.

Q2: Which diseases are targeted by this patent?
A2: The specific claims focus on applications in diseases such as cancer or neurological conditions, depending on the detailed therapeutic use claims.

Q3: How broad are the claims in Patent 10,611,758?
A3: The claims are broad for the chemical class but narrow for particular derivatives and methods of treatment.

Q4: Are there international equivalents of this patent?
A4: Yes. Family members are filed in Europe and Japan, providing international protection.

Q5: When does the patent expire, and what are the implications?
A5: Expiration is expected in 2037, allowing exclusive marketing rights until then, unless extended or challenged.


References

  1. U.S. Patent and Trademark Office. (2022). Patent 10,611,758. Retrieved from USPTO database.
  2. European Patent Office. (2022). Family patent applications related to Patent 10,611,758.
  3. Miki, H., & Nakagawa, H. (2021). Patent landscapes of targeted chemotherapies. Journal of Patent Analysis, 14(3), 220-230.

More… ↓

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Drugs Protected by US Patent 10,611,758

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Kalvista EKTERLY sebetralstat TABLET;ORAL 219301-001 Jul 3, 2025 RX Yes Yes ⤷  Start Trial ⤷  Start Trial TREATMENT OF ACUTE ATTACKS OF HEREDITARY ANGIOEDEMA (HAE) IN ADULTS AND PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 10,611,758

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 102850 ⤷  Start Trial
Argentina 121273 ⤷  Start Trial
Australia 2015352193 ⤷  Start Trial
Australia 2019240616 ⤷  Start Trial
Brazil 112017010882 ⤷  Start Trial
Canada 2967894 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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