Details for Patent: 9,637,512
✉ Email this page to a colleague
Title: | Nucleoside phosphoramidates |
Abstract: | Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. |
Inventor(s): | Chun; Byoung-Kwon (Robbinsville, NJ), Pamulapati; Ganapati Reddy (San Ramon, CA), Rachakonda; Suguna (Twinsburg, OH), Ross; Bruce (El Granada, CA), Sofia; Michael Joseph (Doylestown, PA), Wang; Peiyuan (Totowa, NJ), Zhang; Hai-Ren (San Jose, CA) |
Assignee: | Gilead Pharmasset LLC (Foster City, CA) |
Filing Date: | Jan 10, 2014 |
Application Number: | 14/152,243 |
Claims: | 1. A diastereoselective process for preparing (Sp-4): ##STR00037## comprising: i) reacting compound C: ##STR00038## wherein LG' is p-nitrophenoxide, 2,4-dinitrophenoxide or pentafluorophenoxide with a basic reagent and compound 3: ##STR00039## wherein Z is hydrogen, to obtain Sp-4; or ii) reacting compound C with a basic reagent and compound 3, wherein Z is a protecting group, and deprotecting to obtain S.sub.P-4. 2. The process of claim 1, wherein Z is hydrogen. 3. The process of claim 1, wherein no chromatography is performed. 4. The process of claim 1, wherein LG' is p-nitrophenoxide. 5. The process of claim 1, wherein LG' is pentafluorophenoxide. |