Details for Patent: 9,233,184

Title:	Adhesive preparation
Abstract:	An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m.sup.224 hr measured at a temperature of 40.degree. C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC.sub.0-24 ranging from 3.0 to 60.0 nghr/mL in terms of a mean.+-.standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC.sub.0-24 ranging from 5000 to 13000 nghr/mL in terms of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m.sup.2 and a contact area is 280 cm.sup.2.
Inventor(s):	Tsuruda; Kiyomi (Tosu, JP), Yamasoto; Shinji (Tosu, JP), Shoho; Kouki (Tosu, JP), Nakanishi; Masaru (Tsukuba, JP)
Assignee:	HISAMITSU PHARMACEUTICAL CO., INC. (Tosu-Shi Saga, JP)
Filing Date:	Jul 08, 2014
Application Number:	14/326,014
Claims:	1. An adhesive preparation comprising: a stretchable support and an adhesive layer, wherein the adhesive layer is laminated on at least one side of the support and comprises a thermoplastic elastomer, and 10% by mass or more of methyl salicylate with respect to the total mass of the layer, wherein the whole adhesive preparation has moisture permeability of 1 to 350 g/m.sup.224 hr measured at a temperature of 40.degree. C. and a relative humidity of 90%, and wherein a plasma C.sub.max of salicylic acid is achieved within 12 hours of administration of the adhesive preparation. 2. The adhesive preparation according to claim 1, wherein the adhesive layer comprises a tackifier. 3. The adhesive preparation according to claim 2, wherein the tackifier comprises one or more selected from the group consisting of a rosin-based resin and a petroleum-based resin. 4. The adhesive preparation according to claim 2, wherein the tackifier is present in the adhesive preparation from 10% by mass to 30% by mass with respect to the total mass of the adhesive layer. 5. The adhesive preparation according to claim 1, wherein the stretchable support comprises a longitudinal modulus of 2 to 12 N/5 cm and a lateral modulus of 2 to 8 N/5 cm. 6. The adhesive preparation according to claim 1, wherein the stretchable support comprises a weight per unit area of 80 to 150 g/m.sup.2. 7. The adhesive preparation according to claim 1, wherein the stretchable support comprises an interlock woven fabric. 8. The adhesive preparation according to claim 1, wherein adhesive layer contains 1% by mass or more of I-menthol with respect to the total mass of the layer. 9. The adhesive preparation according to claim 1, wherein the thermoplastic elastomer is one or more selected from the group consisting of a styrene-isoprene-styrene block copolymer, a styrene-butadiene-styrene block copolymer, a styrene-isoprene rubber, a styrene-butadiene rubber, polyisoprene, polybutadiene, and polyisobutylene. 10. The adhesive preparation according to claim 1, wherein the thermoplastic elastomer is present in the adhesive preparation from 25% by mass to 50% by mass with respect to the total mass of the adhesive layer.