|Title:||Inhibitors of bruton's tyrosine kinase|
|Abstract:||Described herein are irreversible kinase inhibitor compounds, exemplified by compounds of the following structure: ##STR00001## methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of a disease such as cancer.|
|Inventor(s):||Honigberg; Lee (San Francisco, CA), Verner; Erik (Belmont, CA), Buggy; Joseph J. (Mountain View, CA), Loury; David (Incline Village, NV), Chen; Wei (Fremont, CA)|
|Assignee:||PHARMACYCLICS LLC (Sunnyvale, CA)|
|Filing Date:||Jan 26, 2015|
|Claims:||1. An irreversible BTK inhibitor having the structure: ##STR00127## wherein ##STR00128## is a non-bicyclic heteroaryl group.|
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