Details for Patent: 9,181,263
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Title: | Inhibitors of bruton's tyrosine kinase |
Abstract: | Described herein are irreversible kinase inhibitor compounds, exemplified by compounds of the following structure: ##STR00001## methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of a disease such as cancer. |
Inventor(s): | Honigberg; Lee (San Francisco, CA), Verner; Erik (Belmont, CA), Buggy; Joseph J. (Mountain View, CA), Loury; David (Incline Village, NV), Chen; Wei (Fremont, CA) |
Assignee: | PHARMACYCLICS LLC (Sunnyvale, CA) |
Filing Date: | Jan 26, 2015 |
Application Number: | 14/605,854 |
Claims: | 1. An irreversible BTK inhibitor having the structure: ##STR00127## wherein ##STR00128## is a non-bicyclic heteroaryl group. |