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Details for Patent: 9,149,539

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Details for Patent: 9,149,539

Title:Crystalline naloxol-PEG conjugate
Abstract: Naloxol-polyethylene glycol conjugates of the formula: ##STR00001## are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.
Inventor(s): Aslund; Bengt (Sodertalje, SE), Aurell; Carl-Johan (Sodertalje, SE), Bohlin; Martin Hans (Sodertalje, SE), Sebhatu; Tesfai (Sodertalje, SE), Ymen; Bo Ingvar (Sodertalje, SE), Healy; Eric Thomas (Madison, AL), Jensen; David Richard (Harvest, AL), Jonaitis; David Thomas (Brookston, IN), Parent; Stephan (West Lafayette, IN)
Assignee: ASTRAZENECA AB (Sodertalje, SE) NEKTAR THERAPEUTICS (San Francisco, CA)
Filing Date:Mar 11, 2015
Application Number:14/645,347
Claims:1. A crystalline phosphate salt of mPEG7-O-naloxol having XRPD d values of (.ANG.) comprising 21.0; 12.1; 7.9; 6.5; 5.3; 4.83; 4.24; 3.81; and 3.75.
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