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Serving leading biopharmaceutical companies globally:

Argus Health
Queensland Health
Daiichi Sankyo
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Colorcon
Dow
Deloitte
Fuji
Moodys
Cerilliant

Generated: November 21, 2017

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Title:Stable pharmaceutical composition and methods of using same
Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
Inventor(s): Manku; Mehar (Birmingham, GB), Osterloh; Ian (Kent, GB), Wicker; Pierre (Mystic, CT), Braeckman; Rene (Richboro, PA), Soni; Paresh (Mystic, CT)
Assignee: Amarin Pharmaceuticals Ireland Limited (Dubin, IE)
Filing Date:Sep 18, 2013
Application Number:14/030,900
Claims:1. A pharmaceutical composition, comprising: omega-3 fatty acids in free acid form including (a) eicosapentaenoic acid in an amount selected from about 1000 mg, about 1650 mg and about 2200 mg; (b) docosahexaenoic acid in an amount of about 20%, by weight of total fatty acids; and docosapentaenoic acid in an amount of about 5%, by weight of total fatty acids.

2. The pharmaceutical composition of claim 1 wherein the eicosapentaenoic acid is present in an amount of about 1000 mg.

3. The pharmaceutical composition of claim 1 wherein the eicosapentaenoic acid is present in an amount of about 1650 mg.

4. The pharmaceutical composition of claim 1 wherein the eicosapentaenoic acid is present in an amount of about 2200 mg.

5. The composition of claim 3 wherein the composition is present in one or more dosage units.

6. The composition of claim 5 wherein the dosage units comprise capsules.

7. A method of reducing triglycerides in a subject in need thereof comprising, administering to the subject daily a composition of claim 6.

8. The method of claim 7 wherein the subject has very high serum triglycerides and is at risk of pancreatitis.

9. A pharmaceutical composition comprising omega-3 fatty acids including: (a) about 1100 mg to about 1200 mg of eicosapentaenoic acid; (b) docosahexaenoic acid, and (c) docosapentaenoic acid, wherein the docosahexaenoic acid comprises not more than about 20% by weight of fatty acids in the composition and the docosapentaenoic acid comprises not more than about 7% by weight of fatty acids present in the composition.

10. The composition of claim 9 wherein the composition is present in one or more dosage units.

11. The composition of claim 10 wherein the dosage units comprise capsules.

12. A pharmaceutical composition comprising omega-3 fatty acids including: (a) about 1700 mg to about 1800 mg of eicosapentaenoic acid; (b) docosahexaenoic acid, and (c) docosapentaenoic acid, wherein the docosahexaenoic acid comprises not more than about 20% by weight of fatty acids in the composition and the docosapentaenoic acid comprises not more than about 7% by weight of fatty acids in the composition.

13. The composition of claim 12 wherein the composition is present in one or more dosage units.

14. The composition of claim 13 wherein the dosage units comprise capsules.

15. A pharmaceutical composition comprising omega-3 fatty acids including: (a) about 2200 mg to about 2300 mg of eicosapentaenoic acid; (b) docosahexaenoic acid, and (c) docosapentaenoic acid, wherein the docosahexaenoic acid comprises not more than about 20% by weight of fatty acids in the composition and the docosapentaenoic acid comprises not more than about 7% by weight of fatty acids in the composition.

16. The composition of claim 15 wherein the composition is present in one or more dosage units.

17. The composition of claim 16 wherein the dosage units comprise capsules.
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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Fish and Richardson
Express Scripts
Covington
Queensland Health
Chinese Patent Office
QuintilesIMS
Dow
Colorcon
UBS

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