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Details for Patent: 9,060,983

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Details for Patent: 9,060,983

Title:Stable pharmaceutical composition and methods of using same
Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
Inventor(s): Manku; Mehar (Birmingham, GB), Osterloh; Ian (Kent, GB), Wicker; Pierre (Mystic, CT), Braeckman; Rene (Richboro, PA), Soni; Paresh (Mystic, CT)
Assignee: Amarin Pharmaceuticals Ireland Limited (Dublin, IE)
Filing Date:Nov 26, 2013
Application Number:14/090,539
Claims:1. A method of lowering triglycerides in a subject with triglycerides of at least 500 mg/dl comprising, administering to the subject daily for a period effective to reduce triglycerides in the subject a pharmaceutical composition comprising omega-3 fatty acids including: (a) about 1100 mg to about 1200 mg of eicosapentaenoic acid; (b) docosahexaenoic acid, and (c) docosapentaenoic acid, wherein the docosahexaenoic acid comprises not more than about 20% by weight of fatty acids in the composition, and the docosapentaenoic acid comprises not more than about 7% by weight of fatty acids present in the composition.

2. The method of claim 1 wherein the composition is present in one or more dosage units.

3. The method of claim 2 wherein the dosage units comprise capsules.

4. A method of lowering triglycerides in a subject with triglycerides of at least 500 mg/dl comprising, administering to the subject daily for a period effective to reduce triglycerides in the subject a pharmaceutical composition comprising omega-3 fatty acids including: (a) about 1700 mg to about 1800 mg of eicosapentaenoic acid; (b) docosahexaenoic acid, and (c) docosapentaenoic acid, wherein the docosahexaenoic acid comprises not more than about 20% by weight of fatty acids in the composition, and the docosapentaenoic acid comprises not more than about 7% by weight of fatty acids in the composition.

5. The method of claim 4 wherein the composition is present in one or more dosage units.

6. The method of claim 5 wherein the one or more dosage units comprise capsules.

7. A method of lowering triglycerides in a subject with triglycerides of at least 500 mg/dl comprising, administering to the subject daily for a period effective to reduce triglycerides in the subject a pharmaceutical composition comprising omega-3 fatty acids including: (a) about 2200 mg to about 2300 mg of eicosapentaenoic acid; (b) docosahexaenoic acid, and (c) docosapentaenoic acid, wherein the docosahexaenoic acid comprises not more than about 20% by weight of fatty acids in the composition, and the docosapentaenoic acid comprises not more than about 7% by weight of fatty acids in the composition.

8. The method of claim 7 wherein the composition is present in one or more dosage units.

9. The method of claim 8 wherein the one or more dosage units comprise capsules.
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