Details for Patent: 9,050,308
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Title: | DPA-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form |
Abstract: | DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented. |
Inventor(s): | Maines; Timothy J. (Potomac, MD), Machielse; Bernardus N M (North Potomac, MD), Mehta; Bharat M. (Mendham, NJ), Wisler; Gerald L. (Windermere, FL), Davidson; Michael H. (Highland Park, IL), Wood; Peter Ralph (Cotherstone, GB) |
Assignee: | Omthera Pharmaceuticals, Inc. (Princeton, NJ) Chrysalis Pharma AG (Sacheln, CH) |
Filing Date: | Jan 04, 2013 |
Application Number: | 13/734,846 |
Claims: | 1. A method of treating severe hypertriglyceridemia, comprising: orally administering a dose of 2-4 grams per day of a pharmaceutical composition comprising: EPA, in a weight percent amount of 50% to 60%; DHA, in a weight percent amount of 17% to 23%; and DPA, in a weight percent amount of 1% to 8%; wherein at least 90% by weight of the polyunsaturated fatty acid in the composition is present in the free acid form, to a patient having pre-treatment serum or plasma triglyceride levels.gtoreq.500 mg/dL, for a duration effective to reduce serum or plasma triglycerides below pre-treatment levels. 2. The method of claim 1, wherein at least 95% by weight of the polyunsaturated fatty acid in the composition is present in the free acid form. 3. The method of claim 1, wherein DPA is present in a weight percent amount of at least 1.5%. 4. The method of claim 3, wherein DPA is present in a weight percent amount of at least 2%. 5. The method of claim 4, wherein DPA is present in a weight percent amount of at least 2.5%. 6. The method of claim 5, wherein DPA is present in a weight percent amount of at least 3%. 7. The method of claim 6, wherein DPA is present in a weight percent amount of at least 3.5%. 8. The method of claim 7, wherein DPA is present in a weight percent amount of at least 4%. 9. The method of claim 7, wherein DPA is present in a weight percent amount of at least 4.5%. 10. The method of claim 1, wherein the dose is 2 grams per day. 11. The method of claim 1, wherein the dose is 4 grams per day. |