Details for Patent: 9,045,475
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Title: | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
Abstract: | Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. |
Inventor(s): | Elmore; Steven W. (Northbrook, IL), Souers; Andrew J. (Evanston, IL), Tao; Zhi-Fu (Gurnee, IL) |
Assignee: | ABBVIE INC. (North Chicago, IL) GENENTECH, INC. (South San Francisco, CA) THE WALTER AND ELIZA INSTITUTE OF MEDICAL RESEARCH (Parkville, AU) |
Filing Date: | Mar 14, 2013 |
Application Number: | 13/830,926 |
Claims: | 1. 4-(4-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}pipera- zin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitr- ophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising an excipient and a therapeutically effective amount of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin- -1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitroph- enyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof. |