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Last Updated: April 26, 2024

Details for Patent: 8,952,049


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Title:Modulators of ATP-binding cassette transporters
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Inventor(s): Ruah; Sara Sabina Hadida (La Jolla, CA), Grootenhuis; Peter Diederik Jan (San Diego, CA), Van Goor; Fredrick F. (San Diego, CA), Zhou; Jinglan (San Diego, CA), Bear; Brian Richard (Oceanside, CA), Miller; Mark Thomas (San Diego, CA), McCartney; Jason (Cardiff-by-the-Sea, CA), Numa; Mehdi Michel Djamel (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Boston, MA)
Filing Date:Feb 28, 2013
Application Number:13/781,392
Claims:1. A method of treating male infertility or pancreatic insufficiency in a patient, comprising the step of administering to said patient a compound which is: ##STR00853## or a pharmaceutically acceptable salt thereof.

2. The method of claim 1, wherein the patient has male infertility.

3. The method of claim 1, wherein the patient has pancreatic insufficiency.

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