Details for Patent: 8,884,019
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Title: | Benzimidazole compound crystal |
Abstract: | A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-- 1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent. |
Inventor(s): | Fujishima; Akira (Hyogo, JP), Aoki; Isao (Hyogo, JP) |
Assignee: | Takeda Pharmaceutical Company Limited (Osaka, JP) |
Filing Date: | Sep 06, 2013 |
Application Number: | 14/020,286 |
Claims: | 1. A method for producing an amorphous of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-- 1H-benzimidazole or salt thereof, which comprises: subjecting a racemate of a compound of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-b- enzimidazole to an optical resolution so that an R-enantiomer of the compound is obtained; adding a solvent comprising ethanol to the obtained R-enantiomer of the compound so that the R-enantiomer of the compound dissolves in the solvent and an R-enantiomer solution is formed; optionally concentrating the R-enantiomer solution so as to form a concentrate; further adding hexane to the R-enantiomer solution or the concentrate; and evaporating the resulting solution to dryness. 2. A method according to claim 1, wherein the optical resolution is carried out by using a chiral column. |