.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 8,884,019

« Back to Dashboard

Details for Patent: 8,884,019

Title:Benzimidazole compound crystal
Abstract: A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-- 1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.
Inventor(s): Fujishima; Akira (Hyogo, JP), Aoki; Isao (Hyogo, JP)
Assignee: Takeda Pharmaceutical Company Limited (Osaka, JP)
Filing Date:Sep 06, 2013
Application Number:14/020,286
Claims:1. A method for producing an amorphous of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-- 1H-benzimidazole or salt thereof, which comprises: subjecting a racemate of a compound of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-b- enzimidazole to an optical resolution so that an R-enantiomer of the compound is obtained; adding a solvent comprising ethanol to the obtained R-enantiomer of the compound so that the R-enantiomer of the compound dissolves in the solvent and an R-enantiomer solution is formed; optionally concentrating the R-enantiomer solution so as to form a concentrate; further adding hexane to the R-enantiomer solution or the concentrate; and evaporating the resulting solution to dryness.

2. A method according to claim 1, wherein the optical resolution is carried out by using a chiral column.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc