Generated: April 27, 2017
|Title:||Benzimidazole compound crystal|
|Abstract:||A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-- 1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.|
|Inventor(s):||Fujishima; Akira (Hyogo, JP), Aoki; Isao (Hyogo, JP)|
|Assignee:||Takeda Pharmaceutical Company Limited (Osaka, JP)|
|Filing Date:||Sep 06, 2013|
|Claims:||1. A method for producing an amorphous of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-- 1H-benzimidazole or salt thereof, which comprises: subjecting a racemate of a compound of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-b- enzimidazole to an optical resolution so that an R-enantiomer of the compound is obtained; adding a solvent comprising ethanol to the obtained R-enantiomer of the compound so that the R-enantiomer of the compound dissolves in the solvent and an R-enantiomer solution is formed; optionally concentrating the R-enantiomer solution so as to form a concentrate; further adding hexane to the R-enantiomer solution or the concentrate; and evaporating the resulting solution to dryness. |
2. A method according to claim 1, wherein the optical resolution is carried out by using a chiral column.
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