.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 8,846,770

« Back to Dashboard

Details for Patent: 8,846,770

Title:Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Inventor(s): Lichter; Jay (Rancho Santa Fe, CA), Vollrath; Benedikt (San Diego, CA), Duron; Sergio G. (San Diego, CA), Scaife; Michael Christopher (Los Altos, CA), Piu; Fabrice (San Diego, CA), Ye; Qiang (San Diego, CA), Dellamary; Luis A. (San Marcos, CA), Lebel; Carl (Malibu, CA), Trammel; Andrew M. (Olathe, KS), Harris; Jeffrey P. (La Jolla, CA)
Assignee: Otonomy, Inc. (San Diego, CA) The Regents of the University of California (Oakland, CA)
Filing Date:Jun 17, 2009
Application Number:12/486,697
Claims:1. A pharmaceutical composition for otic administration comprising: (i) a therapeutically effective amount of a multiparticulate aural pressure modulating agent, or pharmaceutically acceptable salt thereof; (ii) a copolymer of polyoxyethylene and polyoxypropylene in an amount sufficient to provide a gelation temperature of between about 19.degree. C. and about 42.degree. C., a gelation viscosity between about 15,000 cP and about 1,000,000 cP; and a non-gelation viscosity that allows injection with a 18-31 gauge needle through the tympanic membrane on or near the round window membrane; and (iii) having an osmolarity of 100-500 mOsm/L; wherein the pharmaceutical composition for otic administration provides a sustained release of the aural pressure modulating agent to the inner ear for a period of at least 5 days after a single administration; wherein the aural pressure modulating agent is a vasopressin receptor modulator, prostaglandin receptor modulator, estrogen-related receptor beta modulator, a calcium channel blocker, or combinations thereof; provided that the aural pressure modulating agent is a non-corticosteroid aural pressure modulating agent.

2. The pharmaceutical composition for otic administration of claim 1, wherein the pharmaceutical composition for otic administration is an auris-acceptable thermoreversible gel.

3. The pharmaceutical composition for otic administration of claim 1, wherein the aural pressure modulating agent is in the form of a neutral molecule, free acid, free base, a salt, or a combination thereof.

4. The pharmaceutical composition for otic administration of claim 1, wherein the copolymer of polyoxyethylene and polyoxypropylene is poloxamer 407.

5. The pharmaceutical composition for otic administration of claim 1, wherein the aural pressure modulating agent is a prostaglandin.

6. The pharmaceutical composition for otic administration of claim 1, wherein the pharmaceutical composition for otic administration provides a sustained release of the aural pressure modulating agent to the inner ear for a period of at least 7 days after a single administration.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc