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Generated: February 19, 2018

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Title:Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
Abstract: The present invention relates to compounds and processes for preparing compounds of Formula (I), ##STR00001## including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).
Inventor(s): Ronsheim; Melanie Simone (Port Jefferson, NY), Racha; Saibaba (Smithtown, NY), Lawton; Graham Richard (Smithtown, NY), Zhou; Shao Hong (Commack, NY), Kalyan; Yuriy B. (Staten Island, NY), Golden; Michael (Macclesfield, GB), Milne; David (Macclesfield, GB), Telford; Alexander (Macclesfield, GB), Cherryman; Janette (Macclesfield, GB), Boyd; Alistair (Macclesfield, GB), Phillips; Andrew John (Macclesfield, GB), Dedhiya; Mahendra G. (Pomona, NY)
Filing Date:Jun 15, 2012
Application Number:13/524,007
Claims:1. A compound of Formula (VI) or a salt or an analog thereof ##STR00067##

2. The compound according to claim 1, wherein the compound has Formula (VII): ##STR00068##

3. A process for making sodium ({[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]oxy}sulphony- l)oxidanide comprising treating the compound of claim 1 with a protecting group and a carbonylation agent.

4. The process of claim 3, wherein the protecting group is selected from the group consisting of 9-fluorenylmethoxycarbonyl, tert-butoxycarbonyl, benzyloxycarbonyl ethyloxycarbonyl, methyloxycarbonyl, phenoxycarbonyl and allyloxycarbonyl.

5. The process of claim 3, wherein the protecting group is 9-fluorenylmethoxycarbonyl.

6. The process of claim 3, wherein the carbonylation agent is selected from the group consisting of phosgene, triphosgene and carbonyl diimidazole.

7. The process of claim 3, wherein the carbonylation agent is N,N-carbonyl diimidazole.
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