.

Make Better Decisions

  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents
  • Obtain formulation and manufacturing information

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Harvard Business School
AstraZeneca
Fuji
Boehringer Ingelheim
Citi
Cipla
Colorcon
US Army
Merck
McKinsey

Generated: November 20, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title:Abuse deterrent compositions and methods of making same
Abstract: This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
Inventor(s): Kumar; Vijai (Morris Plains, NJ), Dixon; David (Woodside, NY), Tewari; Divya (Suffern, NY), Wadgaonkar; Dilip B. (Suffern, NY)
Assignee: Acura Pharmaceuticals (Chicago, IL)
Filing Date:Feb 27, 2013
Application Number:13/779,071
Claims:1. A therapeutic pharmaceutical composition comprising: a mixture including (a) a water soluble drug susceptible to abuse at about 0.5 to about 25 percent by weight; (b) gel-forming polymer at about 3 to about 40 percent by weight; (c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; and (d) polysorbate 80 at about 1 to 10 percent by weight.

2. The therapeutic pharmaceutical composition of claim 1, wherein the gel-forming polymer is hydroxypropyl methyl cellulose.

3. The therapeutic pharmaceutical composition of claim 2, wherein the hydroxypropyl methyl cellulose has an average molecular weight ranging from about 10,000 to about 1,500,000.

4. The therapeutic pharmaceutical composition of claim 1, wherein the disintegrant comprises croscarmellose sodium.

5. The therapeutic pharmaceutical composition of claim 1, further comprising hydrogenated oil.

6. The therapeutic pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in unit dose form.

7. The therapeutic pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.

8. A therapeutic pharmaceutical composition comprising: a mixture including (a) a water soluble drug susceptible to abuse at about 0.5 to about 25 percent by weight; (b) gel-forming polymer at about 3 to about 40 percent by weight; (c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; (d) sorbitan monooleate at about 1 to 10 percent by weight; and (e) a lubricant including polyethylene glycol.

9. The therapeutic pharmaceutical composition of claim 8, wherein the gel-forming polymer is hydroxypropyl methyl cellulose.

10. The therapeutic pharmaceutical composition of claim 9, wherein the hydroxypropyl methyl cellulose has an average molecular weight ranging from about 10,000 to about 1,500,000.

11. The therapeutic pharmaceutical composition of claim 8, wherein the disintegrant comprises croscarmellose sodium.

12. The therapeutic pharmaceutical composition of claim 8, further comprising microcrystalline cellulose.

13. The therapeutic pharmaceutical composition of claim 8, wherein the pharmaceutical composition is in unit dose form.

14. The therapeutic pharmaceutical composition of claim 8, wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.

15. The therapeutic pharmaceutical composition of claim 8, the lubricant further comprising hydrogenated oil.

16. A therapeutic pharmaceutical composition comprising: a mixture including (a) a water soluble drug susceptible to abuse at about 0.5 to about 25 percent by weight; (b) gel-forming polymer at about 3 to about 40 percent by weight; (c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; (d) polysorbate 80 at about 1 to 10 percent by weight; and (e) a lubricant including polyethylene glycol.

17. The therapeutic pharmaceutical composition of claim 16, wherein the gel-forming polymer is hydroxypropyl methyl cellulose.

18. The therapeutic pharmaceutical composition of claim 17, wherein the hydroxypropyl methyl cellulose has an average molecular weight ranging from about 10,000 to about 1,500,000.

19. The therapeutic pharmaceutical composition of claim 16, wherein the disintegrant comprises croscarmellose sodium.

20. The therapeutic pharmaceutical composition of claim 16, further comprising microcrystalline cellulose.

21. The therapeutic pharmaceutical composition of claim 16, wherein the pharmaceutical composition is in unit dose form.

22. The therapeutic pharmaceutical composition of claim 16, wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.

23. The therapeutic pharmaceutical composition of claim 16, the lubricant further comprising hydrogenated oil.

24. A therapeutic pharmaceutical composition comprising: a mixture including (a) a water soluble drug susceptible to abuse at about 0.5 to about 25 percent by weight; (b) gel-forming polymer at about 3 to about 40 percent by weight; (c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; (d) sorbitan monooleate at about 1 to 10 percent by weight; and (e) microcrystalline cellulose.

25. The therapeutic pharmaceutical composition of claim 24, wherein the gel-forming polymer is hydroxypropyl methyl cellulose.

26. The therapeutic pharmaceutical composition of claim 25, wherein the hydroxypropyl methyl cellulose has an average molecular weight ranging from about 10,000 to about 1,500,000.

27. The therapeutic pharmaceutical composition of claim 24, wherein the disintegrant comprises croscarmellose sodium.

28. The therapeutic pharmaceutical composition of claim 24, further comprising hydrogenated oil.

29. The therapeutic pharmaceutical composition of claim 24, wherein the pharmaceutical composition is in unit dose form.

30. The therapeutic pharmaceutical composition of claim 24, wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.

31. A therapeutic pharmaceutical composition comprising: a mixture including (a) a water soluble drug susceptible to abuse at about 0.5 to about 25 percent by weight; (b) gel-forming polymer at about 3 to about 40 percent by weight; (c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; (d) polysorbate 80 at about 1 to 10 percent by weight; and (e) microcrystalline cellulose.

32. The therapeutic pharmaceutical composition of claim 31, wherein the gel-forming polymer is hydroxypropyl methyl cellulose.

33. The therapeutic pharmaceutical composition of claim 32, wherein the hydroxypropyl methyl cellulose has an average molecular weight ranging from about 10,000 to about 1,500,000.

34. The therapeutic pharmaceutical composition of claim 31, wherein the disintegrant comprises croscarmellose sodium.

35. The therapeutic pharmaceutical composition of claim 31, further comprising hydrogenated oil.

36. The therapeutic pharmaceutical composition of claim 31, wherein the pharmaceutical composition is in unit dose form.

37. The therapeutic pharmaceutical composition of claim 31, wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Medtronic
Colorcon
Boehringer Ingelheim
Dow
US Army
Merck
Harvard Business School
Deloitte
Covington

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot