Details for Patent: 8,802,699
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Title: | Quinuclidine derivatives and medicinal compositions containing the same |
Abstract: | Provided is a pharmaceutical composition comprising: (i) 3-(2-hydroxy-2,2-dithien-2- ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo-[2.2.2]octane or an enantiomer, mixture of enantiomers, or a racemate thereof, wherein an anion X.sup.-with a single negative charge is associated with the positive charge of the nitrogen atom; and (ii) a phosphodiesterase IV inhibitor and methods of using the same. |
Inventor(s): | Fernandez Forner; Maria Dolors (Barcelona, ES), Prat Quinones; Maria (Barcelona, ES), Buil Albero; Maria Antonia (Barcelona, ES) |
Assignee: | Almirall, S.A. (Barcelona, ES) |
Filing Date: | Jul 11, 2013 |
Application Number: | 13/939,742 |
Claims: | 1. A pharmaceutical composition comprising: (i) 3 -(2-hydroxy-2,2-dithien-2-ylacetoxy)-1 -(3 -phenoxypropyl)-1 - azoniabicyclo-[2.2.2]octane or an enantiomer, mixture of enantiomers, or a racemate thereof, wherein an anion X.sup.-with a single negative charge is associated with the positive charge of the nitrogen atom; and (ii) a phosphodiesterase IV inhibitor. 2. The composition of claim 1 further comprising a pharmaceutically acceptable carrier or diluent. 3. The composition of claim 1 wherein the anion X.sup.-is chloride, bromide, iodide, sulfate, nitrate, phosphate, acetate, maleate, fumarate, citrate, oxalate, succinate, tartrate, malate, mandelate, methanesulfonate, p-toluenesulfonate, or trifluoroacetate. 4. The composition of claim 1 which is suitable for inhalation. 5. The composition of claim 1 wherein the composition is a liquid inhalant, powder inhalant, or inhalation aerosol. 6. The composition of claim 2 wherein the pharmaceutically acceptable carrier or diluent is lactose. 7. A method for treating chronic obstructive pulmonary disease, chronic bronchitis, bronchial hyperreactivity, asthma, or rhinitis which method comprises administering to a human or animal patient in need of such treatment an effective amount of the composition of claim 1. 8. The method of claim 7 further comprising administering an effective amount of a steroid. 9. The method of claim 8 further comprising administering an effective amount of a .beta..sub.2 agonist. 10. The method of claim 7 further comprising administering an effective amount of a .beta..sub.2 agonist. |