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Details for Patent: 8,741,963

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Details for Patent: 8,741,963

Title:S1P receptor modulators for treating multiple sclerosis
Abstract: The present invention relates to the use of the S1P receptor modulator 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, administered at a daily dosage of 0.5 mg, for inhibiting or treating neo-angiogenesis associated with multiple sclerosis.
Inventor(s): Hiestand; Peter C. (Allschwil, CH), Schnell; Christian (Hesingue, FR)
Assignee: Novartis AG (Basel, CH)
Filing Date:May 31, 2011
Application Number:13/149,468
Claims:1. A method for inhibiting or treating neo-angiogenesis associated with multiple sclerosis in a subject in need thereof, comprising administering to said subject 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, in free form or in a pharmaceutically acceptable salt form, at a daily dosage of 0.5 mg, absent an immediately preceding loading dose regimen.

2. A method according to claim 1, wherein said multiple sclerosis is primary progressive multiple sclerosis.

3. A method according to claim 1 wherein 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride is administered.

4. A method according to claim 3, wherein said multiple sclerosis is primary-progressive multiple sclerosis.

5. A method according to claim 2, wherein 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride is administered.

6. A method according to claim 1, wherein said multiple sclerosis is relapsing-remitting multiple sclerosis.

7. A method for reducing or alleviating relapses in primary progressive multiple sclerosis in a subject in need thereof, comprising administering to said subject 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, in free form or in a pharmaceutically acceptable salt form, at a daily dosage of 0.5 mg, absent an immediately preceding loading dose regimen.

8. A method according to claim 7, wherein 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride is administered.

9. A method for slowing progression of multiple sclerosis in a subject in the relapsing-remitting phase of primary progressive multiple sclerosis, comprising administering to said subject 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, in free form or in a pharmaceutically acceptable salt form, at a daily dosage of 0.5 mg, absent an immediately preceding loading dose regimen.
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