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Details for Patent: 8,637,646

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Details for Patent: 8,637,646

Title:Growth hormone variants
Abstract: The invention provides variants of human growth hormone having an amino acid substitution at amino acid residue R77, numbered from the N-terminus of 191-amino add human growth hormone as well as nucleic acid molecules encoding these variants.
Inventor(s): Wells; James A. (Burlingame, CA), Cunningham; Brian C. (Piedmont, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Filing Date:May 22, 2002
Application Number:10/153,207
Claims:1. A isolated variant of a human growth hormone having an amino acid substitution at amino acid residue R77, numbered from the N-terminus of 191-amino acid human growth hormone.

2. The variant human growth hormone of claim 1, wherein the substitution is R77C.

3. Isolated DNA having a base sequence that encodes the variant human growth hormone according to claim 2.

4. A vector comprising the isolated DNA molecule of claim 3.

5. A DNA molecule comprising a nucleic acid sequence encoding a variant of a human growth hormone having an amino acid substitution at amino acid residue R77, numbered from the N-terminus of 191-amino acid human growth hormone.

6. A vector comprising the DNA molecule of claim 5.
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