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Healthtrust
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Express Scripts
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Merck
Boehringer Ingelheim
Colorcon

Generated: June 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,536,363

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Title:Compounds and methods for delivery of prostacyclin analogs
Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula: ##STR00001##
Inventor(s): Phares; Ken (Chapel Hill, NC), Mottola; David (Cary, NC)
Assignee: United Therapeutics Corporation (Silver Spring, MD)
Filing Date:Jul 26, 2012
Application Number:13/558,757
Claims:1. A polymorph of a diethanolamine salt of treprostinil that melts at 103.degree. C.

2. A pharmaceutical composition comprising (a) a polymorph of a diethanolamine salt of treprostinil that melts at 103.degree. C. and (b) a pharmaceutically acceptable carrier.

3. The pharmaceutical composition according to claim 2, wherein the formulation exists in a dosage form selected from a capsule, tablet, liquid, or suspension.

4. The polymorph of claim 1, which has an X-ray powder diffraction spectrum as shown in FIG. 15.

5. A method of treating pulmonary hypertension comprising administering to a subject suffering from pulmonary hypertension a pharmaceutical composition as claimed in claim 2.

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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Fish and Richardson
QuintilesIMS
McKesson
Fuji
Accenture
Healthtrust
US Department of Justice
McKinsey

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