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Details for Patent: 8,530,505

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Details for Patent: 8,530,505

Title:Substituted oxazolidinones and their use in the field of blood coagulation
Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) ##STR00001## processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
Inventor(s): Straub; Alexander (Wuppertal, DE), Lampe; Thomas (Wuppertal, DE), Pohlmann; Jens (Wuppertal, DE), Rohrig; Susanne (Essen, DE), Perzborn; Elisabeth (Wuppertal, DE), Schlemmer; Karl-Heinz (Wuppertal, DE), Pernerstorfer; Joseph (Wuppertal, DE)
Assignee: Bayer Intellectual Property GmbH (Monheim am Rhein, DE)
Filing Date:Jan 27, 2012
Application Number:13/360,107
Claims:1. A compound of the formula (I) ##STR00173## wherein R.sup.1 represents an optionally benzo-fused thiophene group which may optionally be mono- or polysubstituted by a radical selected from the group consisting of halogen; cyano; nitro; amino; aminomethyl; (C.sub.1-C.sub.8)-alkyl which for its part may optionally be mono- or polysubstituted by halogen; (C.sub.3-C.sub.7)-cycloalkyl; (C.sub.1-C.sub.8)-alkoxy; imidazolinyl; --C(.dbd.NH)NH.sub.2; carbamoyl; and mono- and di-(C.sub.1-C.sub.4)-alkyl-aminocarbonyl, R.sup.2 represents D-M-A-, where the radical "A" represents optionally substituted ##STR00174## the radical "D" represents optionally substituted ##STR00175## and the radical "M" represents a covalent bond; where when the groups "A" and "D" defined above are substituted they are mono- or polysubstituted by a radical selected from the group consisting of halogen; trifluoromethyl; cyano; nitro; carbamoyl; (C.sub.1-C.sub.6)-alkanoyl; --OR.sup.30; --NR.sup.30R.sup.31, and (C.sub.1-C.sub.6)-alkyl, where R.sup.30 and R.sup.31 are identical or different and independently of one another each represents hydrogen, (C.sub.1-C.sub.4)-alkyl, or C(O)R.sup.33, where R.sup.33 represents (C.sub.1-C.sub.4)-aminoalkyl, or (C.sub.1-C.sub.8)-alkyl, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are identical or different and each represents hydrogen or represents (C.sub.1-C.sub.6)-alkyl or a pharmaceutically acceptable salt or hydrate thereof except for compounds of the formula (I) in which the radical R.sup.1 is an unsubstituted 2-thiophene radical and the radical R.sup.2 is simultaneously a mono- or polysubstituted phenyl radical and the radicals R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each simultaneously hydrogen.

2. The compound of the formula (I) according to claim 1, wherein R.sup.1 represents thiophene which may optionally be mono- or polysubstituted by halogen, amino, aminomethyl or (C.sub.1-C.sub.8)-alkyl, where the (C.sub.1-C.sub.8)-alkyl radical for its part may optionally be mono- or polysubstituted by halogen, R.sup.2 represents D-M-A-, where the radical "A" represents optionally substituted ##STR00176## the radical "D" represents optionally substituted ##STR00177## and the radical "M" represents a covalent bond; where when the groups "A" and "D" defined above are substituted they are mono- or polysubstituted by a radical selected from the group consisting of halogen; trifluoromethyl; cyano; nitro; carbamoyl; (C.sub.1-C.sub.6)-alkanoyl; --OR.sup.30; --NR.sup.30R.sup.31, and (C.sub.1-C.sub.6)-alkyl, where R.sup.30 and R.sup.31 are identical or different and independently of one another each represents hydrogen, (C.sub.1-C.sub.4)-alkyl, (C.sub.1-C.sub.4)-alkanoyl, or (C.sub.1-C.sub.4)-alkylaminocarbonyl, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are identical or different and each represents hydrogen or represents (C.sub.1-C.sub.6)-alkyl or a pharmaceutically acceptable salt or hydrate thereof except for compounds of the formula (I) in which the radical R.sup.1 is an unsubstituted 2-thiophene radical and the radical R.sup.2 is simultaneously a mono- or polysubstituted phenyl radical and the radicals R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each simultaneously hydrogen.

3. The compound of the formula (I) according to claim 1, wherein R.sup.1 represents thiophene which may optionally be mono- or polysubstituted by halogen or by (C.sub.1-C.sub.8)-alkyl, where the (C.sub.1-C.sub.8)-alkyl radical for its part may optionally be mono- or polysubstituted by halogen, R.sup.2 represents D-M-A-, where: the radical "A" represents optionally substituted ##STR00178## the radical "D" represents optionally substituted ##STR00179## and the radical "M" represents a covalent bond; where when the groups "A" and "D" defined above are substituted they are mono- or polysubstituted by a radical selected from the group consisting of halogen; trifluoromethyl; cyano; (C.sub.1-C.sub.3)-alkanoyl; --OH; --NR.sup.30R.sup.31; and (C.sub.1-C.sub.4)-alkyl; where R.sup.30 and R.sup.31 are identical or different and independently of one another each represents hydrogen, (C.sub.1-C.sub.4)-alkyl or (C.sub.1-C.sub.3)-alkanoyl, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are identical or different and each represents hydrogen or represents (C.sub.1-C.sub.6)-alkyl or a pharmaceutically acceptable salt or hydrate thereof except for compounds of the formula (I) in which the radical R.sup.1 is an unsubstituted 2-thiophene radical and the radical R.sup.2 is simultaneously a mono- or polysubstituted phenyl radical and the radicals R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each simultaneously hydrogen.

4. The compound of the formula (I) according to claim 1, wherein R.sup.1 represents 2-thiophene which may optionally be substituted in the 5-position by a radical selected from the group consisting of chlorine, bromine, methyl and trifluoromethyl, R.sup.2 represents D-M-A-, where: the radical "A" represents optionally substituted ##STR00180## the radical "D" represents optionally substituted ##STR00181## and the radical "M" represents a covalent bond; where when the groups "A" and "D" defined above are substituted they are mono- or polysubstituted by a radical selected from the group consisting of halogen; trifluoromethyl; cyano; (C.sub.1-C.sub.3)-alkanoyl; --OH; --NR.sup.30R.sup.31; and (C.sub.1-C.sub.4)-alkyl; where R.sup.30 and R.sup.31 are identical or different and independently of one another each represents hydrogen, (C.sub.1-C.sub.4)-alkyl or (C.sub.1-C.sub.3)-alkanoyl, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are identical or different and each represents hydrogen or represents (C.sub.1-C.sub.4)-alkyl or a pharmaceutically acceptable salt or hydrate thereof except for compounds of the formula (I) in which the radical R.sup.1 is an unsubstituted 2-thiophene radical and the radical R.sup.2 is simultaneously a mono- or polysubstituted phenyl radical and the radicals R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each simultaneously hydrogen.

5. Process for preparing the compound of claim 1, where either according to a process alternative (A) a compound of the formula (II) ##STR00182## in which the radicals R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each as defined in claim 1 is reacted with carboxylic acid of the formula (III) ##STR00183## in which the radical R.sup.1 is as defined in claim 1, or else with a corresponding carbonyl halide, or else with a corresponding symmetric or mixed carboxylic anhydride of the carboxylic acid of the formula (III) defined above in an inert solvent, if appropriate in the presence of an activating or coupling agent and/or a base, to give a compound of the formula (I) ##STR00184## in which the radicals R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each as defined in claim 1, or else according to a process alternative (B) a compound of the formula (IV) ##STR00185## in which the radicals R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each as defined in claim 1, is converted, using a suitable selective oxidizing agent in an inert solvent, into the corresponding epoxide of the formula (V) ##STR00186## in which the radicals R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each as defined in claim 1, and, by reaction in an inert solvent, if appropriate in the presence of a catalyst, with an amine of the formula (VI) R.sup.2--NH.sub.2 (VI), in which the radical R.sup.2 is as defined in claim 1, a compound of the formula (VII) ##STR00187## in which the radicals R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each as defined in claim 1, is initially prepared and, subsequently, in an inert solvent in the presence of phosgene or a phosgene equivalent, cyclized to give a compound of the formula (I) ##STR00188## in which the radicals R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each as defined in claim 1, where--both for process alternative (A) and for process alternative (B)--in the case where R.sup.2 contains a 3- to 7-membered saturated or partially unsaturated cyclic hydrocarbon radical having one or more identical or different heteroatoms from the group consisting of N and S, an oxidation with a selective oxidizing agent to afford the corresponding sulphone, sulphoxide or N-oxide may follow and/or where--both for process alternative (A) and for process alternative (B)--in the case where the compound prepared in this manner has a cyano group in the molecule, an amidination of this cyano group by customary methods may follow and/or where--both for process alternative (A) and for process alternative (B)--in the case where the compound prepared in this manner has a BOC amino protective group in the molecule, removal of this BOC amino protective group by customary methods may follow and/or where--both for process alternative (A) and for process alternative (B)--in the case where the compound prepared in this manner has an aniline or benzylamine radical in the molecule, a reaction of this amino group with a carboxylic acid, carboxylic anhydride, carbonyl chloride, isocyanate, sulphonyl chloride or alkyl halide to give the corresponding derivative may follow and/or where--both for process alternative (A) and for process alternative (B)--in the case where the compound prepared in this manner has a phenyl ring in the molecule, a reaction with chlorosulphonic acid and subsequent reaction with an amine to give the corresponding sulphonamide may follow.

6. A pharmaceutical composition comprising at least one compound of the formula (I) according to claim 1 and one or more pharmacologically acceptable auxiliaries or excipients.

7. A method for treatment of atherosclerosis comprising administering an effective amount of a compound of claim 1 to a patient in need thereof.

8. The compound of claim 1 wherein R.sup.1 represents an optionally substituted 2-thiophene group, and wherein said halogen substituent is chlorine or bromine, and said (C.sub.1-C.sub.8)-alkyl substituent is methyl, where the methyl radical for its part optionally may be mono- or polysubstituted by fluorine.

9. The process of claim 5 wherein in process alternative "A", the corresponding carbonyl halide of carboxylic acid (III) is a carbonyl chloride.

10. The process of claim 5 wherein in process alternative "B", the phosgene equivalent employed in the cyclization of compound (VII) is carbonyldimidazole (CDI).

11. A method for treatment of a thromboembolic disorder comprising administering to a patient in need thereof an effective amount of a compound of claim 1, wherein the thromboembolic disorder is myocardial infarct, pulmonary embolism or deep venous thrombosis.

12. The compound of claim 1 that is purified and isolated.

13. A pharmaceutical composition comprising at least one compound of the formula (I) according to claim 2 and one or more pharmacologically acceptable auxiliaries or excipients.

14. A pharmaceutical composition comprising at least one compound of the formula (I) according to claim 3 and one or more pharmacologically acceptable auxiliaries or excipients.

15. A pharmaceutical composition comprising at least one compound of the formula (I) according to claim 4 and one or more pharmacologically acceptable auxiliaries or excipients.

16. A method for the treatment of atherosclerosis comprising administering an effective amount of the composition of claim 13 to a patient in need thereof.

17. A method for the treatment of myocardial infarct, pulmonary embolism or deep venous thrombosis comprising administering an effective amount of the composition of claim 13 to a patient in need thereof.

18. A method for the treatment of atherosclerosis comprising administering an effective amount of the composition of claim 14 to a patient in need thereof.

19. A method for the treatment of myocardial infarct, pulmonary embolism or deep venous thrombosis comprising administering an effective amount of the composition of claim 14 to a patient in need thereof.

20. A method for the treatment of atherosclerosis comprising administering an effective amount of the composition of claim 15 to a patient in need thereof.

21. A method for the treatment of myocardial infarct, pulmonary embolism or deep venous thrombosis comprising administering an effective amount of the composition of claim 15 to a patient in need thereof.
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