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Details for Patent: 8,445,634

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Details for Patent: 8,445,634

Title:Method of producing FR901228
Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.
Inventor(s): Ueda; Satoshi (Chuo-ku, JP), Watamoto; Yoko (Chuo-ku, JP), Tsuboi; Masaru (Chuo-ku, JP), Kanda; Munekazu (Chuo-ku, JP), Higaki; Tomoji (Chuo-ku, JP), Matsuda; Mitsunori (Chuo-ku, JP)
Assignee: Astellas Pharma Inc. (Tokyo, JP)
Filing Date:May 17, 2012
Application Number:13/473,635
Claims:1. A pharmaceutical composition, comprising: type B crystalline form of FR901228: ##STR00002## a pharmaceutically acceptable carrier.
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