Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of type 2 diabetes|
|Abstract:||The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.|
|Inventor(s):||Edmondson; Scott D. (Clark, NJ), Fisher; Michael (Rahway, NJ), Kim; Dooseop (Westfield, NJ), MacCoss; Malcolm (Seabrook Island, SC), Parmee; Emma R. (Scotch Plains, NJ), Weber; Ann E. (Scotch Plains, NJ), Xu; Jinyou (Scotch Plains, NJ)|
|Assignee:||Merck Sharp & Dohme Corp (Rahway, NJ)|
|Filing Date:||Apr 14, 2011|
|Claims:||1. A pharmaceutical composition comprising (1) a first compound of the formula: ##STR00024## or a pharmaceutically acceptable salt thereof; (2) atorvastatin; and (3) a pharmaceutically acceptable carrier. |
2. A method of treating Type 2 diabetes comprising administering to a mammalian patient in need thereof of such treatment a therapeutically effective amount of a first compound of the formula: ##STR00025## or a pharmaceutically acceptable salt thereof; and atorvastatin.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.