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|Title:||Boron-containing small molecules|
|Abstract:||This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.|
|Inventor(s):||Baker; Stephen J. (Mountain View, CA), Akama; Tsutomu (Sunnyvale, CA), Bellinger-Kawahara; Carolyn (Redwood City, CA), Hernandez; Vincent S. (Watsonville, CA), Hold; Karin M. (Belmont, CA), Leyden; James J. (Malvern, PA), Maples; Kirk (San Jose, CA), Plattner; Jacob J. (Orinda, CA), Sanders; Virginia (San Francisco, CA), Zhang; Yong-Kang (San Jose, CA)|
|Assignee:||Anacor Pharmaceuticals, Inc. (Palo Alto, CA)|
|Filing Date:||Sep 01, 2011|
|Claims:||1. A compound which is 5-(3,4-dicyanophenoxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole. |
2. A pharmaceutical formulation, comprising: (a) a pharmaceutically acceptable excipient; and (b) the compound of claim 1.
3. A compound which is 5-(3,4-dicyanophenoxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical formulation, comprising: (a) a pharmaceutically acceptable excipient; and (b) a compound which is 5-(3,4-dicyanophenoxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, or a pharmaceutically acceptable salt thereof.
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