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Details for Patent: 8,436,033

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Details for Patent: 8,436,033

Title:Methods of treatment using a dexmedetomidine premix formulation
Abstract: The presently disclosed subject matter relates to pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof wherein the composition is formulated as a liquid for parenteral administration to a subject, and wherein the composition is disposed within a sealed container as a premixture. The pharmaceutical compositions can be used, for example, in perioperative care of a patient or for sedation.
Inventor(s): Roychowdhury; Priyanka (Foster City, CA), Cedergren; Robert A. (Libertyville, IL)
Assignee: Hospira, Inc. (Lake Forest, IL)
Filing Date:Nov 15, 2012
Application Number:13/678,260
Claims:1. A method of providing analgesia to a patient in need thereof, the method comprising administering to the patient an effective amount of a composition, wherein the compositon comprises dexmedetomidine or a pharmaceutically acceptable salt thereof at a concentration of about 0.005 to about 50 .mu.g/mL, wherein the composition is a ready to use liquid pharmaceutical composition for parenteral administration to the patient disposed within a sealed glass container.

2. The method of claim 1, wherein the dexmedetomidine or pharmaceutically acceptable salt thereof is at a concentration of about 0.05 to about 15 ug/mL.

3. The method of claim 1, wherein the dexmedetomidine or pharmaceutically acceptable salt thereof is at a concentration of about 0.5 to about 10 ug/mL.

4. The method of claim 1, wherein the dexmedetomidine or pharmaceutically acceptable salt thereof is at a concentration of about 1 to about 7 ug/mL.

5. The method of claim 1, wherein the dexmedetomidine or pharmaceutically acceptable salt thereof is at a concentration of about 4 ug/mL.

6. The method of claim 1, wherein the composition is administered perioperatively.

7. The method of claim 6, wherein the composition is administered before or after surgery.

8. The method of claim 1, wherein the composition is administered to the patient in an intensive care unit.

9. The method of claim 1, wherein the patient is non-ventilated or intubated.

10. The method of claim 1, wherein the patient is critically ill.

11. The method of claim 1, wherein the composition is administered by an intravenous infusion.

12. The method of claim 1, wherein the composition is administered as an anxiolytic.

13. The method of claim 1, wherein the composition is administered as an adjunct to an anesthetic.

14. The method of claim 1, wherein the composition is administered as a sedative.

15. The method of claim 1, wherein the composition is administered as an anti-hypertensive agent.
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