Details for Patent: 8,410,266

Title:	2,4-pyrimidinediamine compounds and their uses
Abstract:	The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
Inventor(s):	Singh; Rajinder (Belmont, CA), Argade; Ankush (Foster City, CA), Clough; Jeffrey (Redwood City, CA), Keim; Holger (Irvine, CA), Bhamidipati; Somasekhar (Foster City, CA), Sylvain; Catherine (Burlingame, CA), Li; Hui (Santa Clara, CA)
Assignee:	Rigel Pharmaceuticals, Inc. (South San Francisco, CA)
Filing Date:	Nov 03, 2011
Application Number:	13/288,813
Claims:	1. A compound according to Formula (I): ##STR00064## or a salt thereof, wherein: one of R.sup.2 and R.sup.4 is a phenyl monosubstituted with (C1-C10) alkyl, --OR.sup.a optionally substituted with one or more of the same or different R.sup.b groups, --O--C(O)OR.sup.a, --O--(CH.sub.2).sub.m--C(O)OR.sup.a, --C(O)OR.sup.a, --O--(CH.sub.2).sub.m--NR.sup.cR.sup.c, --O--C(O)NR.sup.cR.sup.c, --O--(CH.sub.2).sub.m--C(O)NR.sup.cR.sup.c, --O--C(NH)NR.sup.cR.sup.c, --O--(CH.sub.2).sub.m--C(NH)NR.sup.cR.sup.c or --NH--(CH.sub.2).sub.m--NR.sup.cR.sup.c; the other of R.sup.2 and R.sup.4 is a phenyl monosubstituted or disubstituted with R.sup.8; R.sup.2 and R.sup.4 are different; R.sup.5 is --NR.sup.cR.sup.c, CN, or (C1-C6) alkyl optionally substituted with one or more of the same or different R.sup.8 groups; each R.sup.8 independently is R.sup.a or R.sup.b; each R.sup.a is (C1-C6) alkyl; each R.sup.b is --OR.sup.a, --OCF.sub.3, --NR.sup.cR.sup.c, halogen, --CF.sub.3, --CN, --NO.sub.2, --N.sub.3, --SO.sub.2NR.sup.cR.sup.c, --C(O)R.sup.a, --C(O)OR.sup.c, --C(O)NR.sup.cR.sup.c, --C(NH)NR.sup.cR.sup.c, --C(NR.sup.a)NR.sup.cR.sup.c, --C(NOH)R.sup.a, --C(NOH)NR.sup.cR.sup.c; each R.sup.c independently is R.sup.a, hydrogen, or, alternatively, two R.sup.c are taken together with the nitrogen atom to which they are bonded to form a 5- to 8-membered cycloheteroalkyl or heteroaryl; and each m independently is 1 or 2. 2. The compound of claim 1, wherein R.sup.5 is (C1-C4) alkanyl optionally substituted with one or more of the same or different R.sup.8 groups, (C2-C4) alkenyl optionally substituted with one or more of the same or different R.sup.8 groups, or (C2-C4) alkynyl optionally substituted with one or more of the same or different R.sup.8 groups. 3. The compound of claim 2, wherein R.sup.5 is (C1-C4) alkanyl optionally substituted with one or more of the same or different R.sup.8 groups. 4. The compound of claim 3, wherein each R.sup.b is independently --OR.sup.a, --OCF.sub.3, --NR.sup.cR.sup.c, halogen, --CF.sub.3, --CN, --NO.sub.2, --N.sub.3, --SO.sub.2NR.sup.cR.sup.c, --C(O)R.sup.a, --C(O)OR.sup.a or --C(O)NR.sup.cR.sup.c. 5. The compound of claim 4, wherein R.sup.5 is --CF.sub.3. 6. The compound of claim 5, wherein each m is 1. 7. The compound of claim 1, wherein R.sup.4 is selected from the group consisting of 3-chloro-4-methoxy-phenyl, 3-methoxy-4-chlorophenyl, 3-chloro-4-trifluoromethoxy-phenyl, 3-trifluoromethoxy-4-chloro-phenyl, 3,4-dichloro-phenyl, 3,4-dimethoxyphenyl and 3,5-dimethoxyphenyl. 8. The compound of claim 7, wherein R.sup.4 is 3-methoxy-4-chlorophenyl. 9. The compound of claim 1, wherein R.sup.2 is phenyl monosubstituted with --O--(CH.sub.2).sub.m--NR.sup.cR.sup.c. 10. The compound of claim 8, wherein R.sup.2 is phenyl monosubstituted with --O--(CH.sub.2).sub.m--NR.sup.cR.sup.c. 11. The compound of claim 1, wherein R.sup.5 is (C1-C6) alkyl. 12. The compound of claim 10, wherein R.sup.5 is (C1-C6) alkyl. 13. The compound of claim 1, wherein one R.sup.8 is R.sup.b and the other is R.sup.a.